The fourth chronicle of Matthew Bartholomew continues the adventures of the 14th-century Cambridge physician when he is called to attend to two deaths from some poisoned wine. The opening of a new and very well-endowed college has created petty infighting amongst the academics as new appointments are made. The winter and spring have been appallingly wet, there is a fever outbreak amongst the poorer townspeople and the country is not yet fully recovered from the aftermath of the plague.

harles II is well established at White Hall Palace, his mistress at hand in rooms over the Holbein bridge, the heads of some of the regicides on public display. London seethes with new energy, freed from the strictures of the protectorate, but many of its inhabitants have lost their livelihoods. One is Thomas Chaloner, a reluctant spy for the feared secretary of state, John Thurloe, and now returned from Holland in desperate need of employment. 

Hugh of Singleton, fourth son of a minor knight, has been educated as a clerk, usually a prelude to taking holy orders. However, feeling no certain calling despite a lively faith, he turns to the profession of surgeon, training in Paris and then hanging out his sign in Oxford. A local lord asks him to track the killer of a young woman whose bones have been found in the castle cesspit. She is identified as the impetuous missing daughter of a local blacksmith, and her young man, whom she had provoked very publicly, is in due course arrested and sentenced at the Oxford assizes.

Oxford, Spring 1353. When young bookseller Nicholas Elyot discovers the body of student William Farringdon floating in the river Cherwell, it looks like a drowning. Soon, however, Nicholas finds evidence of murder. Who could have wanted to kill this promising student? As Nicholas and his scholar friend Jordain try to unravel what lies behind William's death, they learn that he was innocently caught up in a criminal plot.

In the sapping summer heat of 1665, there is little celebration in London of the naval victory at the Battle of Lowestoft. The King, his retinue and anyone with sufficient means has fled the plague-ridden city, its half-deserted streets echoing the sound of bells tolling the mounting number of deaths. Those who remain clutch doubtful potions to ward off the relentless disease and dart nervously past shuttered buildings, watchful for the thieves who risk their lives to plunder what has been left behind.

Salisbury, 1226. A young pregnant woman is found tangled in reeds in the river Avon, her identity a mystery. Grieving widow Ela Longespée is determined to succeed her husband as sheriff of Salisbury, and quickly takes charge of the investigation. She soon finds herself in the thick of a neighborhood scandal and a struggle to maintain her authority. With multiple suspects, can she identify the true killer? 

The nominal king, Edward VI, is 11 years old. His uncle, Edward Seymour, Lord Hertford, rules as Edward's regent and Protector. In the kingdom, radical Protestants are driving the old religion into extinction, while the Protector's prolonged war with Scotland has led to hyperinflation and economic collapse. Rebellion is stirring among the peasantry. Matthew Shardlake has been working as a lawyer in the service of Henry's younger daughter, the lady Elizabeth. 

Hugh d’Avranches, Earl of Chester, is enraged when his hawk is killed by an arrow in the Forest of Delamere. When two poachers are caught, he orders their execution, yet neither of them fired the arrow. As Ralph Delchard and Gervase Bret come to Cheshire to settle a series of disputes between Church and State, they are guests of the earl. But when they explore the castle and discover that the Prince of Gwynedd is being held there as a hostage, a number of questions arise. 

In medieval England, four children have been murdered, and the townsfolk blame their Jewish neighbors. The doctor chosen to investigate is a woman, Adelia. As she examines the victims and retraces their last steps, she must conceal her true identity in order to avoid accusations of witchcraft. Along the way, she's assisted by Sir Rowley Picot, a man with a personal stake in the investigation. A former Crusader knight, Rowley may be a needed friend - or the fiend for whom they are searching.

The Carolinas, 1699: The citizens of Fount Royal believe a witch has cursed their town with inexplicable tragedies -- and they demand that beautiful widow Rachel Howarth be tried and executed for witchcraft. Presiding over the trial is traveling magistrate Issac Woodward, aided by his astute young clerk, Matthew Corbett. Believing in Rachel's innocence, Matthew will soon confront the true evil at work in Fount Royal....

The Monastery at Whitby is ruled over by the powerful and independent Abbess Hild. But when she needs someone to confide in, she turns to the honest warmth of her friend Fridgyth, the half-pagan herb-wife. A divisive and life-altering decision taken at the Great Synod is swiftly overshadowed as the monastery is ravaged by a deadly plague. As she tends the sick, Fridgyth starts to suspect that not all the deaths are natural. Despite Hild's stern warnings "not to meddle" she sets out to investigate.

It's 1811, and the threat of revolution haunts the upper classes of King George III's England. Then a beautiful young woman is found savagely murdered on the altar steps of an ancient church near Westminster Abbey. A dueling pistol found at the scene and the damning testimony of a witness both point to one man - Sebastian St. Cyr, Viscount Devlin, a brilliant young nobleman shattered by his experience in the Napoleonic Wars.

Gaius Petrius Ruso is a divorced and down-on-his-luck army doctor who has made the rash decision to seek his fortune in an inclement outpost of the Roman Empire, namely Britannia. After a 36-hour shift at the army hospital, he succumbs to a moment of weakness and rescues an injured slave girl, Tilla, from the hands of her abusive owner. And before he knows it, Ruso is caught in the middle of an investigation into the deaths of prostitutes working out of the local bar.

In the year of our Lord 1363, two suspicious deaths in the infirmary of St. Mary's Abbey catch the attention of the powerful John Thoresby, Lord Chancellor of England and Archbishop of York. One victim is a pilgrim, while the second is Thoresby's ne'er-do-well ward, both apparently poisoned by a physic supplied by Master Apothecary Nicholas Wilton. In the wake of these deaths, the archbishop dispatches one-eyed spy Owen Archer to York to find the murderer.

It's 1194, and Sir Faucon de Ramis, the shire's newly appointed keeper of the pleas, must do his duty and make an official declaration of the cause of a miller's death. Saddled with a clerk who names Faucon his "penance", the shire's first crowner must thread the tangled relationships between the sheriff, the village of Priors Holston, and the priory that once ruled it. As a simple task takes a turn to the political, what seems obvious isn't, and what appears safe turns out to be more dangerous than he could imagine.