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A Crack in Creation
- Gene Editing and the Unthinkable Power to Control Evolution
- Narrated by: Erin Bennett
- Length: 9 hrs and 22 mins
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Publisher's Summary
A trailblazing biologist grapples with her role in the biggest scientific discovery of our era: a cheap, easy way of rewriting genetic code, with nearly limitless promise and peril.
Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers and will help address the world's hunger crisis. Yet even the tiniest changes to DNA could have myriad unforeseeable consequences - to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create "better" humans. Writing with fellow researcher Samuel Sternberg, Doudna shares the thrilling story of her discovery and passionately argues that enormous responsibility comes with the ability to rewrite the code of life. With CRISPR, she shows, we have effectively taken control of evolution. What will we do with this unfathomable power?
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What listeners say about A Crack in Creation
Average Customer RatingsReviews - Please select the tabs below to change the source of reviews.
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- DC Mike
- 09-01-17
An easily digestible intro to the future...
Maybe it was driven by my personal curiosity but I found this to be an excellent intro to a topic that I've only encountered in exaggerated news clips or poorly written internet blog ramblings.
20 people found this helpful
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- ThomasC
- 04-03-18
Should be Required Reading
The is the best book on the subject of CRISPR technology I’ve come across so far. It chronicles a pivotal moment in one of the greatest revolutions in the history of life on earth. We all need to be informed about this. Concerns about whether the author is smug or self-serving, as some the reviewers here seem to be obsessing about, pale into insignificance when compared to to importance of this subject to all of us. Read or listen to this book!
13 people found this helpful
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- Laura
- 09-02-17
Compelling and eye opening!
I listened to a podcast on Crispr/Cas9 a few years ago. I wanted to build a greater understand if the technology. It's well written & designed for the non-scientist although I was grateful I paid attention in high school biology.
10 people found this helpful
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- JM
- 01-28-18
Timely thoughts on gene engineering and bioethics
This well-written account gives a first-hand account the thrill of serendipitous scientific discovery as well as the shock of realizing one has let a genie out of the bottle. There is no turning back now that CRISPR in it's many forms exists and is relatively cheap. This book also provides the basic details and perspectives of an important bioethics conversation our global societies must have.
8 people found this helpful
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- Amazon Customer
- 12-27-17
Must Read!
for someone in the medical field with huge curiosity for tech and its impact in the future (and present) of our world, a crack in creation has fulfilled my expectations and sparked a big interest in the field of gene editing.
8 people found this helpful
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- Jacob W. Bitton
- 12-14-18
Bland but interesting subject
It is both an important and interesting subject that we all need to be educated about. But the book seems like a bit too much about the writer. I can't keep from thinking that a lot of what is depicted as thoughts and dilemmas that seem serious were dramatized or boosted for the sake of having a good story - but thats probably me, not being able to trust the good in people. It just seems fake. And i'm not that better educated after listening to the book, Maybe a second listen will make me understand more.
7 people found this helpful
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- Dale
- 10-10-17
Need an advanced science degree
Very important information is contained in the book. But even with my advanced degree in science, I found the book hard to follow at times. Covered the political side well. Brought me up to day in being able to manipulate our DNA. Somewhere down the line gene editing will be a major step in treating disease. Gene editing will lead to significant cultural shifts. How soon and the nature of the cultural shifts, hard to say and not speculated in this book. The authors recommends going slow with this technology.
5 people found this helpful
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- Philomath
- 06-17-17
In to the abyss we ascend, a scary future
Would you listen to A Crack in Creation again? Why?
Probably not
Who was your favorite character and why?
n/a
What about Erin Bennett’s performance did you like?
Good
Was there a moment in the book that particularly moved you?
The whole idea shook me not just moved me
Any additional comments?
This book is a must read for everyone. Humanity is on the cusp of changing itself forever and most don't even know it.
I will ignore the mistakes and unintended consequences of the fascinating CRISPR technology, which are scarier and more prevalent than any technology humans have ever created, and let's pretend everything goes as planned, a highly unlikely scenario.
CRISPR technology is basically the editing of genes with what appears to be the at most accuracy, and it is easier and cheaper than pretty much any other important technology man has recently created.
Creating a mouse that glows in the dark, a pig that is the size of a pet dog, a fish which grows legs are things that have already been achieved. Eliminating heritable disease will be next without a doubt, and what after that? Forget a pretty blue eyed child, or a tall muscular athlete, which I'm sure is coming to a theatre next to you soon.
Let's use our imagination, a larger brain, more memory, more stamina, less sleep, high IQ, a human that has gills and can breath underwater and go down the near endless list of living DNA and pick your choice.
At first glance I think, let this not happen, STOP it right now, then I realise the cat is out of the bag, Pandora's box has been opened. It is the ultimate weapon for domination that has all the hallmarks of Eugenics on steroids.
To quote Steven Pinker let's hope "the better nature of our angels" evolves quickly enough to create future humans with compassion and tolerance. The author, probably a great scientist, is an optimist. I truly hope she's right, otherwise this could be a good explanation to Fermi's Paradox. This could potentially be the last mistake humankind makes. Since the next one if we are lucky will be made by an edited human animal that will need a new name.
Fascinating, incredible and scary science, and not necessarily in this order. Highly recommended for those who want to be spooked.
39 people found this helpful
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- S.Knox
- 01-12-18
Interesting subject matter but not much meat.
The subject is fascinating and the behind the scenes look at the developments leading up to Crispr were very interesting. Most of the book reads like a Nobel application, carefully acknowledging the contributions of others while preserving the authors preeminent role.
7 people found this helpful
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- Mike Hayward
- 09-17-19
Amateur Delivery, Good Content
I learned a number of very interesting things from this book, but it required a bit of slogging. The author devotes significant time to recounting and dramatizing personal encounters, perhaps to lay claim to discoveries or convey her self image, which I found to be tedious and distracting. In other areas of the book she discusses discoveries, developments, implications, possibilities, and her opinions which were generally to the point and well thought out. I am thankful for the audio format as it allows me to glaze over during the sections which should have been edited out on my regular drive to work. I recommend this book if you know nothing about CRISPER, however there may be better, or more succinct books out there.
2 people found this helpful
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- Craig
- 11-05-17
Outstanding Science !
Whilst the science of CRISPR will change everything....and I mean everything, this book is superb at putting the case for both the technical issues and the societal.
One of the best books I have read in a long time!
1 person found this helpful
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- M. Griffiths
- 08-15-17
Gene editing introduction
From the horse's mouth, this book runs thru the discovery of truly transformational biology. Basic concepts are well explained for the uninitiated and the story is both incredibly important and interesting. The author's presentation of her work was not unlikeable and seemed fair - she has been accused of claiming all the credit.
Why not 5 stars? It is a little repetitive and an accompanying pdf is invaluable for this type of book.
1 person found this helpful
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- Anonymous User
- 12-19-21
Highly informotive, the new method is well explain
This book is a nice story of how researchers discovered the simplest form of CRISPR and used it for gene editing. Unfortunately, little was said about the initial discovery of CRISPR. In my opinion, the author greatly overestimates her contribution to the field, hence the story is a bit one-sided. As I understood, most research was actually done by two very smart European postdocs. I'd like to her their story. I guess this would be more like Watson's DNA book with ups and downs, rather than a smooth explanation of things by a big boss.
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- Elitsa Penkova
- 07-16-21
Excellent book
Very engaging book, discussing the two sides of the debate on the future of gene editing. Highly recommend for both science as well as lay audience.
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- Allan Paterson
- 04-28-19
Clear and informative
I was concerned that the biology within this would have been too complex to understand and whilst I don't think for one second I fully understood each point overall this helped me much better understand this amazing break through and the potential it has for us as a species. Enjoyable and well worth a listen.
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- Anonymous User
- 11-21-18
better science than story
Jennifer is clearly a better scientist than storyteller. some sections, specially the future prospects look overly extended
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- Andrew
- 06-16-18
Excellent, informative book.
I seldom write reviews but I have to for this one. Great book, fascinating actually. Great narrator and written in a manner Joe Average (i.e. myself) can understand.
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- Heinrich Ferreira
- 02-15-18
Simply a remarkable book
I simply loved this book. Have not read a more comprehensive coverage and heard a more authoritative review of gene editing than this.
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- Alex Sims
- 02-05-18
Overall very interesting
Some repitition but overall a fascinating overview, would have been good to touch on some of the work being done at competing universities