World renowned neurosurgeon Jon Ritter is on the verge of a medical breakthrough that will change the world. His groundbreaking surgical treatment, using transplanted non-human stem cells, is set to eradicate the scourge of Alzheimer’s disease and give hope to millions. But when the procedure is slated for testing, it all comes to an abrupt and terrifying halt.

When the body of a young woman is found near a trail at a popular ski mountain, the case falls to Joe Gunther and his team at the Vermont Bureau of Investigation (VBI). They quickly have a suspect, Mick Durocher, and a confession, but not everyone on the team is convinced. Despite Mick’s ready admission, investigators quickly sense there might be more going on than is immediately apparent.

Lt. Joe Gunther of the Brattleboro, Vermont, police force has a serious problem: in a community where a decade could pass without a single murder, the body count is suddenly mounting. Innocent citizens are being killed - and others set up - seemingly orchestrated by a mysterious ski-masked man. Signs suggest that a three-year-old murder trial might lie at the heart of things, but it's a case that many in the department would prefer remained closed. A man of quiet integrity, Lt. Gunther knows that he must pursue the case to its conclusion, wherever it leads.

Dr. Alex Cross and Detective John Sampson venture into the rugged Montana wilderness - where they will be the prey. They’re not on the job, but on a personal mission. Until they’re attacked by two rival teams of assassins, controlled by the same mastermind who has stalked Alex and his family for years. Darkness falls. The river churns into rapids. Shots ring out through the forest. 

Evan Smoak is a man with skills, resources, and a personal mission to help those with nowhere else to turn. He’s also a man with a dangerous past. Chosen as a child, he was raised and trained as an Orphan, an off-the-books black box program designed to create the perfect deniable intelligence asset: An assassin. Evan was Orphan X - until he broke with the program and used everything he learned to disappear. But now someone is on his tail.