Deep beneath the Empire State University library, a frustrated student finds the lost legacy of ESU's most infamous alumnus. Victor Von Doom's lab notebooks - instructions for how to build a machine that can pierce the veil between Earth and the netherworld - have fallen into the wrong hands. A gate is opened where none should exist, and someone - or something - has invaded our world. The Fantastic Four would be the team to face such a threat...if they could reach one another. 

The Fantastic Four - the Thing, the Invisible Woman, the Human Torch, and Mr. Fantastic - have used their powers for the betterment of mankind. For years, the world's top scientists have dreamed of creating a quantum computer, a machine that would be infinitely more powerful than any based on the transistor. Now Reed Richards - Mr. Fantastic - has achieved that dream. He has birthed a device capable of creating the unbreakable cipher, predicting the weather, performing calculations, and retrieving knowledge at heretofore unimagined speeds.

They are the Earth's most revered protectors: Reed Richards, Susan Richards, Ben Grimm, and Johnny Storm - the Fantastic Four. Celebrities around the globe and defenders of mankind, these extraordinary individuals have sworn to confront the perils and challenges facing the modern world and each other, always with unyielding courage, unerring wisdom, and an unshakeable familial bond. But their darkest hour may yet be at hand, as humanity's most frightening threat comes violently from beyond the stars...from the depths of the Negative Zone.

The Lizard is wreaking havoc throughout the Everglades, as he seeks a cure for his dual identity as the reptilian villain and the human scientist Dr. Curt Connors - the result of an experiment gone horribly wrong. Spidey's attempts to halt the Lizard's rampage lead him to a web of intrigue and danger that may spell the destruction of a space-shuttle launch. The action heats up as Venom, the alien symbiote who wants Spider-Man dead, arrives, targets the Lizard for death, and won't let anyone stand in his way!

Millionaire industrialist Tony Stark has rejected the lucrative munitions trade that put his company on the map. But he can’t just turn away when the antiterror organization known as S.H.I.E.L.D. asks him for help in its battle against the sinister forces of HYDRA. As the next step in its quest for global domination, the international terrorist cabal is plotting to use cutting-edge technology in a devastating attack on New York City. The source of their advanced weaponry: Stark Industries.

While visiting Japan, Wolverine is recruited to recover a stolen experimental drug, one that has the potential to be a true miracle cure for all human disease - or a sadistic means of enslaving the world. With every hour bringing mankind closer to tragedy, he embarks on a daring mission to identify the thieves and thwart their terrifying agenda.

For years, many have believed that the rise of superpowered mutants represents a threat to the survival of ordinary humans. The uncanny X-Men have dedicated their lives to proving that peaceful coexistence is possible. When a refugee spacecraft crashes on Earth, hounded by a warship bent on its destruction, the X-Men race to the rescue - only to learn that it carries beings of an entirely different order whose very existence may jeopardize life as we know it.

A previously unknown translation of an ancient grimoire, the Darkhold, has been unearthed by archaeologists in South America. But this chilling discovery will have far-reaching effects. Halfway across the globe, the Darkhold is relentlessly pursued by the Cabal of Scrier, an organization devoted to achieving ultimate power through whatever means necessary. And it is through their actions that a darkness from beyond the grave will return to haunt the Spectacular Spider-Man in the form of one of the most frightening and dangerous foes he's ever encountered.... 

The fate of the entire Marvel Universe hangs in the balance as Earth's mightiest heroes face their greatest challenge! Summoned across the stars by the mysterious and unbelievably powerful Beyonder, the Avengers, Spider-Man, the Fantastic Four, and the X-Men are set against their deadliest foes on the mysterious planet known as Battleworld - with the winner promised the ultimate prize. But as battle lines are drawn, new alliances are forged, and old enemies clash, one among them is not willing to settle for anything less than godhood.

When a mysterious spacecraft comes hurtling toward Earth, Carol Danvers - the hero known as Captain Marvel - narrowly prevents it from crashing and killing its pilot. The young woman, Rhi, is an Inhuman, part of a group who rejected that society's caste system and left for the stars in search of a new life. What they found, however, was imprisonment on a planet ruled by a cruel patriarchy. Horrified by the picture the young woman paints, Carol pledges to accompany her back to the planet and pulls together a team of heroes to help.

Betrayed by Earth's heroes and exiled into outer space, the man-monster known as the Incredible Hulk has landed on the distant planet Sakaar, ruled by the tyrannical Red King. Sold into slavery, the Hulk becomes the Green Scar, the planet's mightiest gladiator! But his new masters get more than they bargained for when he forges a bond of brotherhood with his fellow fighters: crafty insectoid Miek, the horrific Brood, wise rock-man Korg, Shadow Warrior Hiroim, noble-born rebel Elloe, and her loyal guardsman Skee. Together, these gladiators start a revolution.

The Avengers journey into deep space, where they unite the intergalactic races against the Builders - deadly aliens who seek to destroy the known galaxy. While the heroes are gone, Thanos sets his sights on Earth, sending the Black Order to launch the assault. It falls to the other heroes of Earth - the Inhumans, the Black Panther, Namor the Sub-Mariner, Doctor Strange, the X-Men, and more - to defend Attilan, Wakanda, Atlantis, and the rest of the planet. To defeat Thanos, the defending forces will need to deploy a new weapon - one that may be as deadly as the invading force. 

Iron Man and Captain America are two core members of the Avengers, the world's greatest superhero team. But when a tragic battle blows a hole in the city of Stamford, killing hundreds of people, the US government demands that all superheroes unmask and register their powers. To Tony Stark - Iron Man - it's a regrettable but necessary step. To Captain America, it's an unbearable assault on civil liberties. 

No evildoers have tried to flatten Peter Parker in weeks. His marriage to Mary Jane is stronger than ever, and he's enjoying his job as a high-school science teacher. Life is good. Naturally, that doesn't last. When Peter learns that his old enemy, the Rhino, is on a rampage in Times Square, he suits up as Spider-Man to stop the destructive villain in his tracks. But he's unexpectedly foiled in his attempts by the Black Cat, a former ally and old flame. The Cat informs Peter that the Rhino is just a distraction - the real threat comes from a group of Ancients.

MODOK, the Mental Organism Designed Only for Killing, is the product of the corrupt scientists of A.I.M (Advanced Idea Mechanics). Iron Man learns that MODOK has turned his back on his creators, destroying an A.I.M. undersea lab, leaving only one devastated survivor. But MODOK's fearsome plan involves more than taking revenge... Now Iron Man must recruit his fellow heroes War Machine, Captain America, and the Black Panther to help him stop MODOK from gathering the materials he needs to create the ultimate weapon - a weapon that could spell humanity's doom!