It’s been a year since Special Agent Susan Marlan and Professor Eric Evans worked a taxing missing persons case together on the Olympic Peninsula. Though the couple have since separated, Eric must reluctantly turn to Susan for advice when a student accused of murdering his ex-girlfriend comes to Eric for help proving his innocence. Susan - busy tracking down two missing employees of San Francisco’s Gruben Dam - warns Eric to be cautious, as the young man has connections to Defenders of the Earth (DOTE), an ecoterror group operating out of San Francisco.

Private investigator Jessica Shaw is used to getting anonymous tips. But after receiving a photo of a three-year-old kidnapped from Los Angeles twenty-five years ago, Jessica is stunned to recognize the little girl as herself. Eager for answers, Jessica heads to LA’s dark underbelly. When she learns that her biological mother was killed the night she was abducted, Jessica’s determined to solve a case the police have forgotten. 

Lieutenant Abby Mullen is no stranger to crisis. As the hostage negotiation instructor for the NYPD, she deals with worst-case scenarios every day. Nothing fazes her anymore. That all changes when she gets a call from Eden Fletcher, a fellow survivor of the infamous Wilcox cult. The two haven’t spoken since the night of a tragic, fiery massacre, when their paths diverged. But now Eden needs Abby’s help: someone has kidnapped her son and is demanding a $5 million ransom. As Abby throws herself into the case, she can’t help but wonder why the kidnapper has targeted Eden.

In the remote forests of Stillwater, Minnesota, you can scream for days and no one will hear you. So when the bodies of two 15-year-old girls are discovered frozen in the snow, Special Agent Nikki Hunt is sure the killer is local: Someone knew where to hide the girls and thought they would never be found. Though Nikki hasn’t been home in 20 years, she knows she must take over the case.

When police investigator Susan Adler is called to the roadside murder of a fellow state trooper, she's tasked with finding the people responsible for the cold-blooded act caught on the trooper's dashboard cam. She traces the car to a nurse who, along with her elderly patient, has been missing for days. At the old man's house, she finds disturbing evidence that instantly revives two cold cases involving long-missing children.

When a body is found stuffed into a barrel at a garbage dump, covered in long red lacerations, Detective Jenna Alton and her new deputy, David Kane, rush to the scene. Nothing ever happens in the small American town of Black Rock Falls, so Jenna believes the victim must be one of two recent missing persons, and she fears for the life of the other. Both were strangers to the town, but there's nothing else to link them. Jenna knows someone must have seen something, but no one's talking.

When Agent Nadine Finch gets the call about the broken body of a young woman found drifting in Sarasota Bay, Florida, she pretends it’s just another case: but deep down, she’s lying to herself. Even though she changed her name, Nadine has always known her family’s dark past would catch up with her eventually.

When Penny Matthews, a seven-year-old girl with blonde curls and a gap-toothed smile, goes missing in the Appalachian mountains, Detective Ellie Reeves is called straight to the scene. According to Penny’s parents, their daughter vanished after a picnic by the creek. All that’s left behind is a pink friendship bracelet etched with “Penny”. 

Laurel Snow wouldn't call hunting a serial killer a vacation, but with a pile of dead bodies unearthed near her Genesis Valley, Washington, hometown, she'll take what she can get. Yet something about this case stirs her in unexpected ways. Like the startling connection she feels to Dr. Abigail Caine, a fiercely intelligent witness with a disturbing knack for making Laurel feel like she has something on her. Then there's Laurel's attraction to Huck Rivers, the fish and wildlife officer guiding her to the crime scene - and into the wilderness.... 

Everyone in the small town of Denton is searching for Isabelle Coleman, a missing 17-year-old girl. All they've found so far is her phone and another girl they didn't even know was missing. Mute and completely unresponsive to the world around her, it's clear this mysterious girl has been damaged beyond repair. All Detective Josie Quinn can get from her is a name: Ramona. Currently suspended from the force for misconduct, Josie takes matters into her own hands as the name leads her to evidence linking the two girls.

For more than twenty-five years, Philadelphia homicide detective Bree Taggert has tucked away the nightmarish childhood memories of her parents’ murder-suicide…. Until her younger sister, Erin, is killed in a crime that echoes that tragic night: innocent witnesses and a stormy marriage that ended in gunfire. There’s just one chilling difference. Erin’s husband, Justin, has vanished.

Three Chicago women have been found strangled, embalmed, and posed as if still alive. Doubting the findings of the local PD’s profiler, the FBI calls on forensic psychologist Zoe Bentley to investigate. Zoe quickly gets off on the wrong foot with her new partner, Special Agent Tatum Gray. Zoe’s a hunter, intense and focused; Tatum’s a smug maverick with little respect for the rules.

As Agent Nadine Finch rushes to investigate the murder of newlywed Nikki Darnell in Ocala National Forest, Florida, fear floods her body. She swore she’d never set foot there again, not since the case 15 years ago which tore her life apart. But taking in the triangular cuts scarring Nikki’s perfect pale skin, she knows she must put her own traumatic past aside to find justice for Nikki and her inconsolable husband.

No one is more familiar with Savannah's dark side than homicide detective and native resident Elise Sandburg. She's been haunted for years by her own mysterious past: She was abandoned as a baby in one of the city's ancient cemeteries, and it’s rumored that she is the illegitimate daughter of an infamous Savannah witch doctor. The local Gullah culture of voodoo and magic is one that few outsiders can understand, least of all Elise’s new partner.

When 12-year-old Isabella Farner disappears, Agent Tori Hunter races to the scene. Witnesses—including her partner’s son, who was biking home with Isabella—saw a man throw her into the back of his blue van and speed away. Terrified that a child she loves like her own might be next, Tori knows every second counts in the hunt for the missing girl. Isabella’s distraught parents insist no one would want to harm their perfect family. But soon a photo of Isabella looking terrified is discovered, holding a copy of today’s newspaper.