When a private plane whisks CDC epidemiologist Madeline Hamilton to Washington, DC, for an urgent medical symposium, she knows something significant is underway - but she doesn’t expect to face the most disturbing medical mystery of her career. A debilitating neurological toxin has stricken the children of several political families, and one of them is the son of US President Anna Moreland.

Avery Keene, a brilliant young law clerk for the legendary Justice Howard Wynn, is doing her best to hold her life together - excelling in an arduous job with the court while also dealing with a troubled family. When the shocking news breaks that Justice Wynn - the cantankerous swing vote on many current high-profile cases - has slipped into a coma, Avery’s life turns upside down. She is immediately notified that Justice Wynn has left instructions for her to serve as his legal guardian and power of attorney.

In the lucrative world of finance, Vincent, Jules, Sylvie, and Sam are at the top of their game. They’ve mastered the art of the deal and celebrate their success in style - but a life of extreme luxury always comes at a cost. Invited to participate in an escape room as a team-building exercise, the ferociously competitive co-workers crowd into the elevator of a high rise building, eager to prove themselves. But when the lights go off and the doors stay shut, it quickly becomes clear that this is no ordinary competition: they’re caught in a dangerous game of survival.

When talented journalist Penelope “Casey" Harrison starts to research a piece about the #MeToo movement that includes an incident in her own life that she has been trying to put out of her mind for years, she does not realize the young man who drugged and assaulted her at a fraternity house party in college is now a wealthy, powerful industrialist on the eve of a merger that will make him a billionaire - and who will do anything, even murder, to cover his tracks.

Lark has good things coming: a career as a board-game designer and a whirlwind romance with a handsome investor, who is so compassionate and supportive, he’s almost too good to be true. Jessica has always been cautious, but she can’t resist a brilliant TED-talking visionary. Holly has settled into a comfortable life with Jack, her husband of nearly twenty years. They’ve raised three children, they own a beautiful home, and they’ve founded a worthy charity. Lark, Jessica, and Holly are three strangers with so much in common it hurts. Their one and only is one and the same.

There’s been a breakthrough on the campus of Caltech. A discovery. An invention. One so startling and surprisingly sinister that the inventor can’t tell a soul. Precariously poised at the center of the action is Victoria Pixler, a bioengineering student with a tragic past, a passionate quest, and a brilliant mind. After a decade of dedication, she’s just completed her life’s work only to have her dream shattered and her career terminated - by the least likely suspect.

Unexpectedly reunited after six years, high school sweethearts Devin Shanahan and Grace Harrington cross paths and have a whirlwind wedding. A lot can change in six years, however, and they must figure out how to make their two independent lives mesh. Unable to disclose his CIA job to his new wife, when Devin is assigned a top-secret mission to Hong Kong, he tells Grace part of the truth: that he is going to work abroad for six months in finance. When the mission turns deadly and Devin doesn't know whom to trust, he must make the most difficult decision of his life to keep Grace safe.

Newly minted chief resident at Boston Memorial Hospital Noah Rothauser is swamped in his new position, from managing the surgical schedules to dealing with the fallouts from patient deaths. Known for its medical advances, the famed teaching hospital has fitted several ORs as "hybrid operating rooms of the future" - an improvement that seems positive until an anesthesia error during a routine procedure results in the death of an otherwise healthy man.

George Wilson, M.D., a radiology resident in Los Angeles, is about to enter a profession on the brink of an enormous paradigm shift, foreshadowing a vastly different role for doctors everywhere. The smartphone is poised to take on a new role in medicine, no longer as a mere medical app but rather as a fully customizable personal physician capable of diagnosing and treating even better than the real thing. It is called iDoc. George's initial collision with this incredible innovation is devastating.

Will physicist Martin Riley get the rewards he feels he deserves? He's discovered a way to receive news stories from two weeks in the future but the Government has cloaked the technology in secrecy. Riley sees the danger in altering the Timestream but despite his warnings, politicians on both sides of the Atlantic make radical alterations to political events. The first temporal alteration saves Princess Diana, the next saves the Twin Towers, but ripples travel far ahead and disturb Earth's future civilisation. The Timestream must be realigned, but at what cost?

Technology has developed to the point where a person can be placed in a sleep state: a cross between suspended animation and a drug-induced coma. Just as the trial of the new technology is being completed, an unusual comet is discovered approaching Earth, bringing with it radiation that will wipe out all life on the planet.

Gage Stewart has spent five years trying to overcome his past. Once an abused and troubled teenager, he has worked tirelessly to move beyond the fateful day he was manipulated into holding a group of teenagers hostage. Now, with a new identity and a college degree in criminal psychology, he accepts an unlikely job teaching others what to do during mass shootings.

Juan Gutierrez, a cancer researcher, uncovers what he believes to be the key to conquering humanity's susceptibility to cancer. But others are interested in using the new genetic algorithm for very different applications. Nate Carrington, an FBI forensic analyst, has been struggling with several cold cases when he's alerted to an incident at a nearby ranch. It's a case of a newborn calf who is found in the middle of a herd of dead cattle. It provides a single link to Nate's other cold cases....

Special Agent Lisa Tanchik is the best at taking down cybercriminals. So when the FBI discovers a multibillion-dollar black market online, she’s tasked with finding the creator and bringing him to justice. Donning one of her many digital disguises, Tanchik goes undercover into the network. Brilliant college student Nate Fallon started his site as an idealistic experiment. But his platform has made illegal trade not only more efficient - but also more dangerous. Now the FBI aren’t the only ones out to get him. 

After her rescue of nearly 50 kidnapped children made international headlines, Amara Alvarez gets what she's worked for: a transfer to San Antonio's Homicide Division. Reality sets in quickly, though, as her first case, the suspicious death of a teenager at a crowded local water park, brings chaos to her personal life. As the investigation moves forward, and she increases the pressure on the suspects, Amara finds herself under attack by cybercriminals. Her every move is being potentially watched online, and she's forced to resort to unconventional methods to find the killer.