• Madness and Memory

  • The Discovery of Prions - A New Biological Principle of Disease
  • By: Stanley B. Prusiner
  • Narrated by: Joe Barrett
  • Length: 10 hrs
  • 4.5 out of 5 stars (34 ratings)

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Madness and Memory  By  cover art

Madness and Memory

By: Stanley B. Prusiner
Narrated by: Joe Barrett
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Publisher's Summary

In 1997, Stanley B. Prusiner received a Nobel Prize, the world's most prestigious award for achievement in physiology or medicine. That he was the sole recipient of the award for the year was entirely appropriate. His struggle to identify the agent responsible for ravaging the brains of animals suffering from scrapie and mad cow disease, and of humans with Creutzfeldt-Jakob disease, had been waged largely alone and, in some cases, in the face of strenuous disagreement.

In this book, Prusiner tells the remarkable story of his discovery of prions - infectious proteins that replicate and cause disease but surprisingly contain no genetic material - and reveals how superb and meticulous science is actually practiced with talented teams of researchers who persevere. He recounts the frustrations and rewards of years of research and offers fascinating portraits of his peers as they raced to discover the causes of fatal brain diseases. Prusiner's hypothesis, once considered heresy, now stands as accepted science and the basis for developing diagnoses and eventual cures. He closes with a meditation on the legacy of his discovery: What will it take to cure Alzheimer's, Parkinson's, Lou Gehrig's, and other devastating diseases of the brain?

©2014 Stanley B. Prusiner, MD (P)2015 Audible, Inc.

What listeners say about Madness and Memory

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Spectacular

Wow. I have had an interest in prion diseases for years, and this book was absolutely superb. The writing painted an amazing picture of his process in answering the question: What is the infectious agent responsible for CJD, Kuru, and other spongiform encephalopathies? The relentless search for empirical data outlined in this book was captivating. I will absolutely listen again and also find a hard copy. I hope to add to the knowledge of prior diseases and help discover ways to mitigate the devastating effects caused by these insidious little denatured proteins in the future.

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Prions a ground breaking discovery

Fascinating review of a Nobel laureate’s journey to the discovery of prions.Highly recommend the book.

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  • Amazon Customer
  • 04-10-22

excellent and riveting story.

the fascinating and some controversial story of the prion, a Class of proteins that lack genetic material and yet still spread like a virus, appear sporadically and are the cause of a small number of rare genetic disease. How can this be,? well, listen on and find out in the author's own words how he an his team turned our conventional understanding of the germ theory of disease on its head and discovered a whole new disease process. A process who's understanding affects more people than you think. Anyone with a neurodegenerative disorder now benefits from a whole new understanding of their disease thanks to Prusiner and his colleagues.