Talia is being held at a correctional facility for adolescent girls in the forested mountains of Colombia after committing an impulsive act of violence that may or may not have been warranted. She urgently needs to get out and get back home to Bogotá, where her father and a plane ticket to the United States are waiting for her. If she misses her flight, she might also miss her chance to finally be reunited with her family.

It's Holy Week in the small town of Las Penas, New Mexico, and 33-year-old unemployed Amadeo Padilla has been given the part of Jesus in the Good Friday procession. He is preparing feverishly for this role when his 15-year-old daughter, Angel, shows up pregnant on his doorstep and disrupts his plans for personal redemption. With weeks to go until her due date, tough, ebullient Angel has fled her mother's house, setting her life on a startling new path. 

Coming of age as a free-born Black girl in Reconstruction-era Brooklyn, Libertie Sampson was all too aware that her purposeful mother, a practicing physician, had a vision for their future together: Libertie would go to medical school and practice alongside her. But Libertie, drawn more to music than science, feels stifled by her mother’s choices and is hungry for something else - is there really only one way to have an autonomous life? And she is constantly reminded that, unlike her mother who can pass, Libertie has skin that is too dark.

1970s, Mexico City. Maite is a secretary who lives for one thing: the latest issue of Secret Romance. While student protests and political unrest consume the city, Maite escapes into stories of passion and danger. Her next-door neighbor, Leonora, a beautiful art student, seems to live a life of intrigue and romance that Maite envies. When Leonora disappears under suspicious circumstances, Maite finds herself searching for the missing woman - and journeying deeper into Leonora’s secret life of student radicals and dissidents.

Opal is a fiercely independent young woman pushing against the grain in her style and attitude, Afro-punk before that term existed. Coming of age in Detroit, she can’t imagine settling for a 9-to-5 job - despite her unusual looks, Opal believes she can be a star. So when the aspiring British singer/songwriter Neville Charles discovers her at a bar’s amateur night, she takes him up on his offer to make rock music together for the fledgling Rivington Records.

As this urgent, genre-defying book opens, a woman who has recently been elevated to prominence for her social media posts travels around the world to meet her adoring fans. She is overwhelmed by navigating the new language and etiquette of what she terms "the portal," where she grapples with an unshakable conviction that a vast chorus of voices is now dictating her thoughts. When existential threats - from climate change and economic precariousness to the rise of an unnamed dictator and an epidemic of loneliness - begin to loom, she posts her way deeper into the portal's void.

When 29-year-old Sunday Brennan wakes up in a Los Angeles hospital, bruised and battered after a drunk driving accident she caused, she swallows her pride and goes home to her family in New York. But it’s not easy. She deserted them all — and her high school sweetheart — five years before with little explanation, and they've got questions.

Years of trying unsuccessfully to conceive a child have broken more than Angie DeSaria’s heart. Following a painful divorce, she moves back to her small Pacific Northwest hometown and takes over management of her family’s restaurant. In West End, where life rises and falls like the tides, Angie’s fortunes will drastically change yet again when she meets and befriends a troubled young woman. 

In its heyday, The Golden Hotel was the crown jewel of the hotter-than-hot Catskills vacation scene. For more than sixty years, the Goldman and Weingold families - best friends and business partners - have presided over this glamorous resort which served as a second home for well-heeled guests and celebrities. But the Catskills are not what they used to be - and neither is the relationship between the Goldmans and the Weingolds.

Through poverty, adolescence, and a fraught relationship with her mother, Ashley Ford wishes she could turn to her father for hope and encouragement. There are just a few problems: he’s in prison, and she doesn’t know what he did to end up there. She doesn’t know how to deal with the incessant worries that keep her up at night, or how to handle the changes in her body that draw unwanted attention from men. In her search for unconditional love, Ashley begins dating a boy her mother hates.

The child of a married Japanese aristocrat and her African American GI lover, Nori is an outsider from birth. Her grandparents take her in, only to conceal her, fearful of a stain on the royal pedigree that they are desperate to uphold in a changing Japan. Obedient to a fault, Nori accepts her solitary life, despite her natural intellect and curiosity.

Willis Wu doesn’t perceive himself as a protagonist even in his own life: He’s merely Generic Asian man. Sometimes he gets to be Background Oriental Making a Weird Face or even Disgraced Son, but he is always relegated to a prop. Yet every day he leaves his tiny room in a Chinatown SRO and enters the Golden Palace restaurant, where Black and White, a procedural cop show, is in perpetual production. He’s a bit player here, too, but he dreams of being Kung Fu Guy - the most respected role that anyone who looks like him can attain. At least that’s what he has been told.

Edie is stumbling her way through her 20s - sharing a subpar apartment in Bushwick, clocking in and out of her admin job, making a series of inappropriate sexual choices. She is also haltingly, fitfully giving heat and air to the art that simmers inside her. And then she meets Eric, a digital archivist with a family in New Jersey, including an autopsist wife who has agreed to an open marriage - with rules.

Ike Randolph has been out of jail for 15 years, with not so much as a speeding ticket in all that time. But a Black man with cops at the door knows to be afraid. The last thing he expects to hear is that his son Isiah has been murdered, along with Isiah’s white husband, Derek. Ike had never fully accepted his son but is devastated by his loss. 

Twenty-six-year-old editorial assistant Nella Rogers is tired of being the only Black employee at Wagner Books. Fed up with the isolation and microaggressions, she’s thrilled when Harlem-born and bred Hazel starts working in the cubicle beside hers. They’ve only just started comparing natural hair care regimens, though, when a string of uncomfortable events elevates Hazel to Office Darling, and Nella is left in the dust.