Germany, 1942. Franciscan friar Anton Starzmann is stripped of his place in the world when his school is seized by the Nazis. He relocates to a small German hamlet to wed Elisabeth Herter, a widow who seeks a marriage - in name only - to a man who can help raise her three children. Anton seeks something too - atonement for failing to protect his young students from the wrath of the Nazis. But neither he nor Elisabeth expects their lives to be shaken once again by the inescapable rumble of war. 

On a Mississippi morning in 1859, Emily Matthews begs her father to save a slave, Nathan, about to be auctioned away from his family. Judge Matthews is an abolitionist who runs an illegal school for his slaves, hoping to eventually set them free. One, a woman named Ginny, has become Emily's companion and often her conscience - and understands all too well the hazards an educated slave must face. Yet even Ginny could not predict the tangled, tragic string of events set in motion as Nathan's family arrives at the Matthews farm.

The Overland Trail, 1853: Naomi May never expected to be widowed at 20. Eager to leave her grief behind, she sets off with her family for a life out West. On the trail, she forms an instant connection with John Lowry, a half-Pawnee man straddling two worlds and a stranger in both. But life in a wagon train is fraught with hardship, fear, and death. Even as John and Naomi are drawn to each other, the trials of the journey and their disparate pasts work to keep them apart.

Moments after Lisbeth is born, she’s taken from her mother and handed over to an enslaved wet nurse, Mattie, a young mother separated from her own infant son in order to care for her tiny charge. Thus begins an intense relationship that will shape both of their lives for decades to come. Though Lisbeth leads a life of privilege, she finds nothing but loneliness in the company of her overwhelmed mother and her distant, slave-owning father.

Pino Lella wants nothing to do with the war or the Nazis. He's a normal Italian teenager - obsessed with music, food, and girls - but his days of innocence are numbered. When his family home in Milan is destroyed by Allied bombs, Pino joins an underground railroad helping Jews escape over the Alps, and falls for Anna, a beautiful widow six years his senior. In an attempt to protect him, Pino's parents force him to enlist as a German soldier - a move they think will keep him out of combat.

Ernt Allbright, a former POW, comes home from the Vietnam war a changed and volatile man. When he loses yet another job, he makes an impulsive decision: He will move his family north, to Alaska, where they will live off the grid in America’s last true frontier.

In June, 1954, eighteen-year-old Emmett Watson is driven home to Nebraska by the warden of the juvenile work farm where he has just served fifteen months for involuntary manslaughter. His mother long gone, his father recently deceased, and the family farm foreclosed upon by the bank, Emmett's intention is to pick up his eight-year-old brother, Billy, and head to California where they can start their lives anew. But when the warden drives away, Emmett discovers that two friends from the work farm have hidden themselves in the trunk of the warden's car.

After the loss of her mother and her own battle with breast cancer, Joanna Teale returns to her graduate research on nesting birds in rural Illinois, determined to prove that her recent hardships have not broken her. She throws herself into her work from dusk to dawn, until her solitary routine is disrupted by the appearance of a mysterious child who shows up at her cabin barefoot and covered in bruises. The girl calls herself Ursa, and she claims to have been sent from the stars to witness five miracles.

For years, rumors of the "Marsh Girl" have haunted Barkley Cove, a quiet town on the North Carolina coast. So in late 1969, when handsome Chase Andrews is found dead, the locals immediately suspect Kya Clark, the so-called Marsh Girl. But Kya is not what they say. Sensitive and intelligent, she has survived for years alone in the marsh that she calls home, finding friends in the gulls and lessons in the sand.

The morning of January 12, 1888, was unusually mild, following a punishing cold spell. It was warm enough for the homesteaders of the Dakota Territory to venture out again and for their children to return to school without their heavy coats - leaving them unprepared when disaster struck. At the hour when most prairie schools were letting out for the day, a terrifying, fast-moving blizzard blew in without warning. Schoolteachers as young as 16 were suddenly faced with life-and-death decisions.

From the day that old Nana Reja found a baby abandoned under a bridge, the life of a small Mexican town forever changed. Disfigured and covered in a blanket of bees, little Simonopio is for some locals the stuff of superstition, a child kissed by the devil. But he is welcomed by landowners Francisco and Beatriz Morales, who adopt him and care for him. As he grows up, Simonopio becomes a cause for wonder to the Morales family, because when the uncannily gifted child closes his eyes, he can see what no one else can - visions of all that’s yet to come, both beautiful and dangerous.

It's 1924 in Branchville, South Carolina, and three women have come to a crossroads. Gertrude, a mother of four, must make an unconscionable decision to save her daughters. Retta, a first-generation freed slave, comes to Gertrude's aid by watching her children, despite the gossip it causes in her community. Annie, the matriarch of the influential Coles family, offers Gertrude employment at her sewing circle, while facing problems of her own at home.

Growing up on their hardscrabble farm in rural Kentucky, 15-year-old Albertina "Bertie" Winslow has learned a lot from her mama, Polly. She knows how to lance a boil, make a pie crust, butcher a pig, and tend to every chore that needs doing. What she doesn't know, but is forced to reckon with all too soon, is how to look after children as a mother should. When Polly succumbs to a long illness, Bertie takes on responsibility for her four younger siblings and their dissolute, unreliable daddy.  

1932: Located on the banks of the Gilead River in Minnesota, Lincoln School is home to hundreds of Native American boys and girls who have been separated from their families. The only two white boys in the school are orphan brothers Odie and Albert, who, under the watchful eyes of the cruel superintendent Mrs. Brickman, are often in trouble for misdeeds both real and imagined. The two boys' best friend is Mose, a mute Native American who is also the strongest kid in school. And they find another ally in Cora Frost, a widowed teacher who is raising her little girl, Emmy, by herself. 

Colorado, 1880. Gracy Brookens has delivered hundreds, maybe thousands of babies in her lifetime. The only midwife in a small mining town tucked in the Tenmile Range, Gracy is a gifted and important resource for the women of her hardscrabble community. For years she has advised expectant mothers through their pregnancies, guided them through the tortures of labor, and then helped them heal.