The prize-winning and best-selling author of Say Nothing presents a grand, devastating portrait of three generations of the Sackler family, famed for their philanthropy, whose fortune was built by Valium and whose reputation was destroyed by OxyContin. Empire of Pain is a masterpiece of narrative reporting and writing, exhaustively documented and ferociously compelling.

In this extraordinary work, Beth Macy takes us into the epicenter of a national drama that has unfolded over two decades. From the labs and marketing departments of big pharma to local doctor's offices; wealthy suburbs to distressed small communities in Central Appalachia; from distant cities to once-idyllic farm towns; the spread of opioid addiction follows a tortuous trajectory that illustrates how this crisis has persisted for so long and become so firmly entrenched.

American Pain chronicles the rise and fall of this game-changing pill mill and how it helped tip the nation into its current opioid crisis. The narrative, which swings back and forth between Florida and Kentucky, is populated by a diverse cast of characters.

In 2014, Theranos founder and CEO Elizabeth Holmes was widely seen as the female Steve Jobs: a brilliant Stanford dropout whose start-up “unicorn” promised to revolutionize the medical industry with a machine that would make blood testing significantly faster and easier. Backed by investors such as Larry Ellison and Tim Draper, Theranos sold shares in a fund-raising round that valued the company at more than $9 billion, putting Holmes’ worth at an estimated $4.7 billion. There was just one problem: The technology didn’t work.

The opioid epidemic has been described as "one of the greatest mistakes of modern medicine." But calling it a mistake is a generous rewriting of the history of greed, corruption, and indifference that pushed the US into consuming more than 80 percent of the world's opioid painkillers. Journeying through lives and communities wrecked by the epidemic, Chris McGreal reveals not only how Big Pharma hooked Americans on powerfully addictive drugs but the corrupting of medicine and public institutions that let the opioid makers get away with it.

From the New York Times best-selling author of Dreamland, a searing follow-up that explores the terrifying next stages of the opioid epidemic and the quiet yet ardent stories of community repair. 

Three out of four people addicted to heroin probably started on a prescription opioid, according to the director of the Centers for Disease Control and Prevention. In the United States alone, 16,000 people die each year as a result of prescription opioid overdose. But perhaps the most frightening aspect of the prescription drug epidemic is that it's built on well-meaning doctors treating patients with real problems.

Nearly every American knows someone who has been affected by the opioid crisis. Addiction is a trans-partisan issue that impacts individuals from every walk of life. Millions of Americans are tired of watching their loved ones die while politicians ignore this issue. Where is the solution? Where is the hope? Where's the outrage? Ryan Hampton understands firsthand how easy it is to develop a dependency on opioids, and how destructive it can quickly become. Now, he is waging a permanent campaign to change our way of thinking about and addressing addiction in this country.

In 1929, in the blue-collar city of Portsmouth, Ohio, a company built a swimming pool the size of a football field; named Dreamland, it became the vital centre of the community. Now, addiction has devastated Portsmouth, as it has hundreds of small rural towns and suburbs across America—addiction like no other the country has ever faced. How that happened is the riveting story of Dreamland. 

Trauma is a fact of life. Veterans and their families deal with the painful aftermath of combat; one in five Americans has been molested; one in four grew up with alcoholics; one in three couples have engaged in physical violence. Dr. Bessel van der Kolk, one of the world’s foremost experts on trauma, has spent more than three decades working with survivors. In The Body Keeps the Score, he uses recent scientific advances to show how trauma literally reshapes both body and brain, compromising sufferers’ capacities for pleasure, engagement, self-control, and trust.  

This deeply personal and illuminating memoir about her 15-year struggle with heroin, Khar sheds profound light on the opioid crisis and gives a voice to the over two million people in America currently battling with this addiction. Growing up in LA, Erin Khar hid behind a picture-perfect childhood filled with excellent grades, a popular group of friends and horseback riding. After first experimenting with her grandmother’s expired painkillers, Khar started using heroin when she was thirteen.

Pharmaceutical breakthroughs such as antibiotics and vaccines rank among some of the greatest advancements in human history. Yet, exorbitant prices for life-saving drugs, safety recalls affecting tens of millions of Americans, and soaring rates of addiction and overdose on prescription opioids have caused many to lose faith in drug companies. Now, Americans are demanding a national reckoning with a monolithic industry.

Known to mankind since prehistoric times, opium is arguably the oldest and most widely used narcotic. Opium: A History traces the drug's astounding impact on world culture - from its religious use by prehistoric peoples to its influence on the imaginations of the Romantic writers; from the earliest medical science to the Sino-British opium wars. 

In his best seller Wheat Belly, Dr. William Davis changed the lives of millions of people by teaching them to remove grains from their diets to reverse years of chronic health damage. In Undoctored, he goes beyond cutting grains to help you take charge of your own health. This groundbreaking exposé reveals how millions of people are given dietary recommendations crafted by big business, are prescribed unnecessary medications, and undergo unwarranted procedures to feed revenue-hungry healthcare systems.

A bioethicist’s eloquent and riveting memoir of opioid dependence and withdrawal - a harrowing personal reckoning and clarion call for change not only for government but medicine itself, revealing the lack of crucial resources and structures to handle this insidious nationwide epidemic.