Jason Bennett is a suburban dad who owns a court-reporting business, but one night, his life takes a horrific turn. He is driving his family home after his daughter’s field hockey game when a pickup truck begins tailgating them, on a dark stretch of road. Suddenly two men jump from the pickup and pull guns on Jason, demanding the car. A horrific flash of violence changes his life forever.

Last year, Maddie Schwartz was a happy, even pampered housewife. This year, she’s bolted from her marriage of almost 20 years, determined to make good on her youthful ambitions to live a passionate, meaningful life. Drawing on her own secrets, she helps Baltimore police find a murdered girl - assistance that leads to a job at the city’s afternoon newspaper, the Star. Working at the newspaper offers Maddie the opportunity to make her name, and she has found just the story to do it: a missing woman whose body was discovered in the fountain of a city park lake.

The Garretts take their first and last family vacation in the summer of 1959. They hardly ever leave home, but in some ways they have never been farther apart. Mercy has trouble resisting the siren call of her aspirations to be a painter, which means less time keeping house for her husband, Robin. Their teenage daughters, steady Alice and boy-crazy Lily, could not have less in common. Their youngest, David, is already intent on escaping his family's orbit, for reasons none of them understand. 

Jess needs a fresh start. She’s broke and alone, and she’s just left her job under less than ideal circumstances. Her half brother, Ben, didn’t sound thrilled when she asked if she could crash with him for a bit, but he didn’t say no, and surely everything will look better from Paris. Only when she shows up - to find a very nice apartment, could Ben really have afforded this? - he’s not there. The longer Ben stays missing, the more Jess starts to dig into her brother’s situation, and the more questions she has.

On a searing August day, Melisandre Harris Dawes committed the unthinkable: She left her two-month-old daughter locked in a car while she sat nearby on the shores of the Patapsco River. Melisandre was found not guilty by reason of criminal insanity, although there was much skepticism about her mental state. Freed, she left the country, her husband, and her two surviving children, determined to start over.

Heloise considers it a blessing to be a person who seldom attracts attention. In her suburb, she's just a mom, the young widow with the forgettable job, who somehow never misses a soccer game. In the state capital, she's the redheaded lobbyist with a good cause and a mediocre track record. But in discreet hotel rooms throughout the area, she's the woman of your dreams - if you can afford the hourly fee. For more than a decade, Heloise believed she was safe, managing to keep up this rigidly compartmentalized life. But her secret life is under siege. One county over, another so-called suburban madam has been found dead in her car, an apparent suicide.

If Avery Chambers can’t fix you in 10 sessions, she won’t take you on as a client. Her successes are phenomenal - she helps people overcome everything from domineering parents to assault - and almost absorbs the emptiness she sometimes feels since her husband’s death. Marissa and Mathew Bishop seem like the golden couple - until Marissa cheats. She wants to repair things, both because she loves her husband and for the sake of their eight-year-old son. After a friend forwards an article about Avery, Marissa takes a chance on this maverick therapist.

Thirty years ago, Wilde was found as a boy living feral in the woods, with no memory of his past. Now an adult, he still doesn't know where he comes from, and another child has gone missing. No one seems to take Naomi Pine's disappearance seriously, not even her father - with one exception. Hester Crimstein, a television criminal attorney, knows through her grandson that Naomi was relentlessly bullied at school. Hester asks Wilde - with whom she shares a tragic connection - to use his unique skills to help find Naomi.

By age 24, Letty Davenport has seen more action and uncovered more secrets than many law enforcement professionals. Now a recent Stanford grad with a master’s in economics, she’s restless and bored in a desk job for US Senator Colles. Letty’s ready to quit, but her skills have impressed Colles, and he offers her a carrot: feet-on-the-ground investigative work, in conjunction with the Department of Homeland Security. 

Liz Kelsey promised herself she’d never again spy on her feckless husband, Phil. But then she discovers a string of suggestive texts on his secret burner phone. Even worse, he’s flirting with the woman who shook their unstable marriage once before. But knowledge is power. What’s more dangerous - what Liz knows or what Phil doesn’t know? 

Chemist Elizabeth Zott is not your average woman. In fact, Elizabeth Zott would be the first to point out that there is no such thing as an average woman. But it’s the early 1960s and her all-male team at Hastings Research Institute takes a very unscientific view of equality. Except for one: Calvin Evans; the lonely, brilliant, Nobel–prize nominated grudge-holder who falls in love with—of all things—her mind. True chemistry results. But like science, life is unpredictable.

Frankie Elkin is an average middle-aged woman, a recovering alcoholic with more regrets than belongings. But she spends her life doing what no one else will - searching for missing people the world has stopped looking for. When the police have given up, when the public no longer remembers, when the media has never paid attention, Frankie starts looking. A new case brings her to Mattapan, a Boston neighborhood with a rough reputation. She is searching for Angelique Badeau, a Haitian teenager who vanished from her high school months earlier. 

Merritt Coletto and her husband, Luca, have the life they dreamed of: a coastal home, a promising future, and a growing family. That dream ends with a late-night knock on the door. Weak, broken, and emaciated, it’s Luca’s first wife, Lydia. Missing for ten years, presumed dead, and very much alive, she has quite a story. Racked with guilt over the beautiful life they’ve built, Merritt and Luca agree to help get Lydia back on her feet - it’s the least they can do. But the more enmeshed Lydia becomes in Merritt’s family, the more questions Merritt has. 

Cassie thinks she has met the perfect man. Joel is sweet, handsome, romantic, and best of all, he’s crazy about Cassie. She thinks she’s found the guy she’ll spend the rest of her life with. Have children with. Grow old with. Yes, she knows about his perfect ex-girlfriend, Francesca. The beautiful, brilliant chef, beloved by all his friends. But she thinks Francesca is out of the picture. She thinks Francesca is gone for good. Think again, Cassie.

She calls herself Hope Miller, but she has no idea who she actually is. Fifteen years ago, she was found in a small New Jersey town thrown from an overturned vehicle, with no clue to her identity. Doctors assumed her amnesia was a temporary side effect of her injuries, but she never regained her memory. Hope eventually started a new life with a new name in a new town that welcomed her, yet always wondered what she may have left behind - or been running from. Now, she’s leaving New Jersey to start over once again.