Across the length and breadth of the galaxy, humankind celebrates its salvation and relishes the prospect of a return to peace. But the war against the orks has driven the political bedrock of the Imperium, exposing its rotten core. One man, one powerful man, decides he has the solution and launches a campaign of destruction so terrible that thousands of years later his actions will still be viewed with horror.

A great darkness has befallen the galaxy, and the armies of Chaos are rampant. To survive, humanity must retaliate and take back what they have lost. By the will of the reborn primarch, Roboute Guilliman, is the Indomitus Crusade launched - a military undertaking that eclipses all others in known history. From the Throneworld of Terra does the Avenging Son hurl his fleets, their mission the very salvation of mankind.

The skitarii are the soldiers of the Machine God, the tireless legions of the Adeptus Mechanicus. Holy warriors, they carry the word of the Omnissiah across the galaxy, destroying impure machines and spearheading the Quest for Knowledge. A discovery of ancient technology sends a skitarii legion into battle on a forge world overrun by Chaos. When a cataclysm cuts him off from his tech-priest overseers, Stroika must rally his forces and battle both corrupt machines and Chaos Space Marines.

In the hellish sprawl of Imperial Terra, Ordo Hereticus Inquisitor Erasmus Crowl serves as a stalwart protector, for even the Throneworld is not immune to the predations of its enemies. In the course of his duty, Crowl becomes embroiled in a dark conspiracy, one that leads all the way to the halls of the Imperial Palace. As he plunges deeper into the shadowy underbelly of the many palace districts, his investigation attracts the attention of hidden forces, and soon he and his acolyte Spinoza are being hunted.

The Horus Heresy is over. The traitor Legions have scattered, fleeing the wrath of a vengeful Imperium. The World Eaters are leaderless, their primarch missing and their greatest hero, Khârn, locked in a coma. The surviving Legionaries have turned upon themselves, their Butcher's Nails driving them to ever-greater acts of berserk savagery. Poised on the brink of destruction, the Legion needs direction. 

After seven years of bitter war, the end has come at last for the conflict known infamously as the Horus Heresy. Terra now lies within the Warmaster’s sights, the Throneworld and the seat of his father’s rule. Horus’ desire is nothing less than the death of the Emperor of Mankind and the utter subjugation of the Imperium. He has become the ascendant vessel of Chaos and amassed a terrible army with which to enact his will and vengeance. But the way to the Throne will be hard as the primarch Rogal Dorn, the Praetorian and protector of Terra, marshals the defences.

The Great Crusade is ending. The Emperor has returned to Terra, while Horus remains among the stars to complete the unification of humanity. As the Imperial armies fight the final battles of the age, Remembrancer Solomon Voss seeks the answer to one question—why does Sigismund, First Captain of the Imperial Fists and greatest champion of the Legions, believe that war will not end? Granted a rare audience with the master of the Templars, the answer takes Voss on a revelatory journey to a time before Sigismund became a Space Marine.

Fell times have come to the galaxy. Cadia has fallen, destroyed by the onslaught of Chaos. A Great Rift in the warp has opened, and from its depths spew daemons and the horrors of Old Night. But all hope is not lost… A hero, long absent, has returned, and with him comes the wrath of the Ultramarines reborn. Roboute Guilliman has arisen to lead the Imperium out of darkness on a crusade the likes of which has not been seen since the fabled days of the Emperor. But never before have the forces of Ruin amassed in such numbers, and nowhere is safe from despoliation. 

The Blood Angels Chapter of Space Marines is under threat. Having obliterated all human life in the Red Scar region of space, the largest tendril of Hivefleet Leviathan ever seen in the Imperium has converged and is making relentlessly for Baal. To face this awesome foe, Commander Dante has called upon the Successor Chapters of the ancient Ninth Legion. The Sons of Sanguinius gather in numbers not seen since the dark days of the Horus Heresy. 

Legend tells of a foolhardy expedition, led by the radical Magos Telok, that ventured out into the unknown space beyond the Halo Worlds in search of the 'Breath of the Gods' - an arcane device with the power to unmake and reshape the very stars themselves. Thousands of years later, the ambitious Lexell Kotov musters his Adeptus Mechanicus Explorator fleet and sets out to follow in mad old Telok's footsteps. 

Ufthak Blackhawk and the green tide descend upon Hephaesto - an Adeptus Mechanicus forge world bristling with loot - only to find it already under siege by the notorious Freebooter Kaptin Badrukk. When his warboss, Da Biggest Big Mek, orders temporary co-operation, Ufthak seeks to make a name for himself by crushing some of the Imperium’s most advanced defenders and claiming the greatest prize. 

In the Pandorax System, on the death world of Pythos, an ancient secret that has laid buried for millennia. Ignorant of this terror, troopers of the Catachan 183rd, stranded on Pythos, find themselves under attack by the forces of Chaos. Daemons in their thousands flock the sky, and none other than Warmaster Abaddon leads the attack. With the Death Guard and Black Legion arrayed against them, the Catachans appear to be doomed, until salvation arrives in the form of the entire Dark Angels Chapter. But what is the so-called 'Damnation Cache'?  

Phil Kelly continues his look at the life of Commander Farsight with his first campaign against the full might of the Imperium and shows how the T'au Empire's technological superiority fares against Imperial grit.

Exile to the miserable world of Sedh, the disgraced Necron Lord Oltyx is consumed with bitterness. Once heir to the throne of a dynasty, he now commands nothing but a dwindling garrison of warriors, in a never-ending struggle against Ork invaders. Oltyx can think of nothing but the prospect of vengeance against his betrayers, and the reclamation of his birthright. But the Orks are merely the harbingers of a truly unstoppable force. Unless Oltyx acts to save his dynasty, revenge will win him only ashes. 

For many long years, the ork warlord known as the Overfiend of Octarius has bedevilled the Imperium, ruling his alien empire in the heart of the Emperor's realm. Now, at last, three Chapters of Space Marines come together to destroy the greenskin menace and restore Imperial rule. The Salamanders, White Scars and Raven Guard, together with their allies from the Astra Militarum and bolstered by the aid of the mercurial alien eldar, fall upon the worlds of Octarius system with chainsword and bolter, bringing death to the orks.