Liverpool, 1963. Mary Kate Malone is 17 and bitterly unhappy that her father has married again after the death of her mother. On her last day at school, she decides to leave home in Tarabeg and head for Liverpool to find her mother's sister. But nothing goes to plan. Within hours of disembarking, she finds herself penniless and alone, with no place to stay and no idea how she will survive. Meanwhile, back in Ireland, a long-buried secret is about to come to light and a day of reckoning, in the shape of a stranger from America, will set an unstoppable chain of events in motion.

It is 1953, and five girls are arriving to start their training at St Angelus Hospital. Dana has escaped from her family farm in Ireland. Victoria is running away from an aristocratic background. Beth is an army brat and throws her lot in with bitchy Celia Forsyth, and Pammy has come from the wrong side of the tracks. When an unknown girl is admitted after a botched backstreet abortion, a tragedy begins to unfold which will rock the world of St Angelus to its foundations.

Christmas is one of the most harrowing times of year for the nurses of St Angelus Hospital.  The Matron takes on Tilly, a new clerk, to ease the load in the busy festive period. Tilly is bright and hardworking, but she is keeping a secret from her colleagues. Everyday Tilly makes a heartbreaking decision - but she has no other choice. If Matron - with her traditional values and strict discipline -learnt the truth about her new clerk, Tilly's career would be ruined. Could Matron ever forgive the deceit?

As a small child, Nellie Peace was always dreaming but sensed her mother’s rejection. Abandoned and sent into service at Beaumont House at an early age, Nellie is lost and alone until she meets the unpredictable and reclusive artist Lucas Harrington and falls in love with him. This unlikely association between master and servant is encouraged by Lucas’ gentle-natured Aunt Alice, as Lucas sees something unusual in Nellie and is compelled to paint her. Broken promises lead to inevitable heartbreak, and Nellie flees Beaumont House in disgrace for London.

Cambridgeshire - March 1939. As the clouds of war begin to gather in Europe, the Talbot family of rural Blackberry Farm will be torn apart, just as so many families all over the world will be. Life will never be the same again. Whilst in London, the Salmons family will feel the pain of parting and loss. Brought together by war, the two families become intertwined and, as the outlook looks bleak, they must draw on each other’s strength to fight through the hard times.

1949. Peggy and Able Ronoscki's seaside cafe in Devon is thriving, and their twins, Fay and Freddie, are growing up fast. To pursue her daughter’s destiny, Fay must train in London and Peggy is faced with a dilemma of moving the family back to London once more. Meanwhile, Peggy’s elder daughter, Janet, has her own troubles. She fears her husband is having an affair and is desperately unhappy. Peggy is torn two ways and can only hope that a reunion with her friends at Christmas can help resolve her problems. 

Liverpool, 1939. Bella Rogers thought her life was just starting; she can’t wait to get married to her childhood sweetheart, Bobby. But when war is declared and Bobby is called up, his letters stop, leaving Bella heartbroken and alone. Then her family is torn apart by tragedy when her angelic 5-year-old sister dies from a terrible illness. They can barely afford a funeral, but the church is packed with the entire community, devastated for their loss. Grieving for her sister and lost love, Bella finds a job at the Bryant and May factory, making matches.

Bridget Milligan has donned a uniform and joined the nursing services where she becomes intrigued with the miracles of modern medicine. She’s also torn between family loyalty, her new career and Lyndon O’Neill, the love of her life. Is it too impossible to hope that everything will come out right in the end? Phyllis Harvey is still serving in Malta where she sees the casualties of war first hand. Finally it seems like Phyllis is blessed with true in love, but fate can sometimes be a rocky road and nothing is that certain.

Jane Hadley has nothing to lose when she runs away to join the Women's Auxiliary Air Force. Whatever faces her in war-torn London can't be any worse than staying at home with her abusive father. The city is nothing like she could have imagined, but she's soon on the move, travelling from base to base for her top-secret training. Making plenty of friends along the way, it doesn't take long for Jane to embrace her growing confidence - especially under the attentive eye of dashing Officer Oscar Stanton.

Born on a farm outside Edinburgh in the mid-19th century, Agnes Watt is embraced by family, community, and tradition. Her youthful hopes and dreams are quashed but she falls in love and marries William Miller, a Gordon Highlander. Life spirals into dark places as the couple become ensnared in the nightmare that descended on the Scottish working class during the industrial revolution. The triumphs of the great Victorian era came at an appalling human cost and Agnes fights against disease and grinding poverty.

London, 1938: Lizzie Larch is a 20-year-old hat maker in London's east end. She is happy and popular, but she carries a secret. Seven years ago she was viciously attacked and recovered in a private sanatorium where she miscarried a child. Lizzie has no memory of the night of the attack, but secrets cannot stay secret for too long. When she starts courting her boss' nephew, a shocking revelation surfaces; threatening to destroy their new-found happiness.

1940, Liverpool: Alice Turner and her best friend, Millie Markham, work for the war effort at Rootes munitions factory, making shell caps and Halifax bombers. Alice’s sweetheart, Terry, is home from the front for a brief period of leave. But the honeymoon is soon over. Terry must go back to the dangers of Nazi-occupied France, and the ever-present air raid sirens quickly bring Alice back down to earth. 

After the heartbreak of World War Two, newlywed midwife Cathy hoped Liverpool life would offer some joy. But a terrible miscarriage and the escape of her abusive stepfather Jack from prison make happiness hard to find. Meanwhile, Cathy’s beloved granny is ailing. Whilst at the hospital, Cathy sees her midwifery friends, who are planning to open a home for unmarried mothers. After losing a baby of her own, Cathy would love to help, but for now, she must take care of her grandmother.  

London, 1910. Lily is 10 years old when she realises her grandmother, a washerwoman, is seriously ill. She's determined to do what she can to help and keep her grandmother's illness a secret - even from her beloved twin, Artie. When tragedy strikes and the twins are faced with the prospect of a workhouse or an orphanage, a benefactor offers to take Artie in and educate him. All Artie's needs will be taken care of - but the gentleman has no use for a girl. As the orphan twins grow up and take different paths, their new lives are beyond anything they could have imagined. 

In February, 1922, at the western-most entrance to Victoria Station in Manchester, a massive plaque was unveiled. Beneath a vast tiled map showing the lines of the Lancashire and Yorkshire Railway network, a series of seven bronze panels recorded the names of the men of the Lancashire and Yorkshire Railway who gave their lives for King and Country in the Great War - a total of 1,460 names. In March, 1940, a group of women of varying ages and backgrounds stands in front of the memorial, ready to do its bit in this new World War....