Peter Parker is caught in a complicated web. Working in a cutting-edge laboratory, he's a young scientist who's trying to make a difference. Yet he's constantly burdened by the responsibilities of his second career as the crime-fighting Spider-Man. Wilson Fisk - the so-called Kingpin of Crime - has returned to New York, establishing himself publicly as an altruistic entrepreneur and philanthropist. Spider-Man knows better, but he can't uncover Fisk's scheme, which, if executed, will make the crime lord too big to fail. 

A previously unknown translation of an ancient grimoire, the Darkhold, has been unearthed by archaeologists in South America. But this chilling discovery will have far-reaching effects. Halfway across the globe, the Darkhold is relentlessly pursued by the Cabal of Scrier, an organization devoted to achieving ultimate power through whatever means necessary. And it is through their actions that a darkness from beyond the grave will return to haunt the Spectacular Spider-Man in the form of one of the most frightening and dangerous foes he's ever encountered.... 

In a Manhattan warehouse, an innocent man has been murdered during a mysterious crime. Evidence points to the involvement of Venom - the alien symbiote obsessed with Spider-Man's destruction. Yet Venom has always safeguarded innocent lives. Has Venom gone completely around the bend, or is there another suspect? Spider-Man thinks there is more to the crime than meets the eye. The specter of the Hobgoblin, one of Spider-Man's nastiest foes, falls on a series of thefts and leads the web-slinger to a deadly secret that may cause New York's destruction. 

A scientist finds a way to create perfect humans, heal the lame, and cure the sick. Dr. Aron Esterhazy's new formula can even turn ordinary people into superbeings. Everyone who finds out about it wants it - but who will control it?

J. Jonah Jameson, the publisher of the Daily Bugle, has denounced Spider-Man from the beginning, convincing New Yorkers to see him as a criminal and a menace. But when a robot attack on Manhattan injures Peter Parker's students and Jameson blames Spider-Man, their feud takes on a personal dimension. 

Stark Enterprises has unleashed the Infinite Engine, which promises to be an energy source unlike anything ever seen before. But saboteurs from both A.I.M. and Hydra have set their sights on the engine as well - along with Dr. Doom. When a respected scientist is killed and the Engine taken over, Spiderman and Iron Man join forces to safeguard the Infinite Engine - and all of humanity. 

The Lizard is wreaking havoc throughout the Everglades, as he seeks a cure for his dual identity as the reptilian villain and the human scientist Dr. Curt Connors - the result of an experiment gone horribly wrong. Spidey's attempts to halt the Lizard's rampage lead him to a web of intrigue and danger that may spell the destruction of a space-shuttle launch. The action heats up as Venom, the alien symbiote who wants Spider-Man dead, arrives, targets the Lizard for death, and won't let anyone stand in his way!

No evildoers have tried to flatten Peter Parker in weeks. His marriage to Mary Jane is stronger than ever, and he's enjoying his job as a high-school science teacher. Life is good. Naturally, that doesn't last. When Peter learns that his old enemy, the Rhino, is on a rampage in Times Square, he suits up as Spider-Man to stop the destructive villain in his tracks. But he's unexpectedly foiled in his attempts by the Black Cat, a former ally and old flame. The Cat informs Peter that the Rhino is just a distraction - the real threat comes from a group of Ancients.

On several occasions, a half-dozen of Spider-Man's greatest enemies have banded together as the Sinister Six. Now, at the behest of a deadly benefactor known only as the Gentleman, the Chameleon has been tasked with assembling a new Sinister Six with the most ambitious scheme yet! Soon, he has recruited the Vulture, freed Electro and Dr. Octopus from prison, and been joined by the Gentleman's mysterious ward, Pity. That only leaves Mysterio, but the master of illusion has a plan of his own. 

While visiting Japan, Wolverine is recruited to recover a stolen experimental drug, one that has the potential to be a true miracle cure for all human disease - or a sadistic means of enslaving the world. With every hour bringing mankind closer to tragedy, he embarks on a daring mission to identify the thieves and thwart their terrifying agenda.

What drives the Man Without Fear? Matt Murdock was raised by a single father, an over-the-hill prizefighter with one last chance to make good - a chance that cost him his life. Taunted and tormented by other children, Matt's life was irrevocably altered after he was blinded by radioactive materials while saving the life of an old man. The payoff? An unbreakable will and a keen intelligence, helping focus the super-senses with which he was blessed during the accident. His story is one of love, pain, disappointment, and strength.

Brian Timilty is running for mayor on an anti-superhero ticket, and the amazing Spider-Man is his biggest target. But Timilty is secretly the pawn of Tyler Stewart, a wealthy businessman seeking to take over New York's mobs. To ensure his success, Stewart hires two of Spider-Man's deadliest foes, Electro and the Rhino, and executes a plan guaranteed to keep the wall-crawler from interfering with his grand designs: He frames Spider-Man for a grisly murder! Forced into hiding, Spider-Man must find a way to clear his name without being shot on sight, for he is wanted dead or alive.

In the spirit of the popular Marvel comic book, this exciting new anthology has over a dozen original tales that span the career of the amazing Spider-Man. Stan Lee, Spidey's co-creator, and Kurt Busiek, the award-winning writer of the Untold Tales of Spider-Man comic book, present these new stories from his earliest days as a costumed hero and beyond. 

In the clear blue skies above Long Island, two airplanes collide. Tony Stark watches the scene in horror and wishes he had the technology that is almost within his reach - a new hyperintelligent instant control system that could have given the aircraft advance warning. But Stark, an obsessive, increasingly troubled recluse, doesn’t know that his invention has been compromised. 

Beginning with a novella by Spider-Man's co-creator Stan Lee and veteran Marvel writer Peter David retelling the wall-crawler's origin, this exciting anthology has original stories featuring one of the world's most enduring heroes.