Theo Byrne is a promising young astrobiologist who has found a way to search for life on other planets dozens of light years away. He is also the widowed father of a most unusual nine-year-old. His son, Robin, is funny, loving, and filled with plans. He thinks and feels deeply, adores animals, and can spend hours painting elaborate pictures. He is also on the verge of being expelled from third grade for smashing his friend's face with a metal thermos.  

In Orfeo, Powers tells the story of a man journeying into his past as he desperately flees the present. Composer Peter Els opens the door one evening to find the police on his doorstep. His home microbiology lab - the latest experiment in his lifelong attempt to find music in surprising patterns - has aroused the suspicions of Homeland Security. Panicked by the raid, Els turns fugitive. As an Internet-fueled hysteria erupts, Els - the "Bioterrorist Bach" - pays a final visit to the people he loves, those who shaped his musical journey.

After several years living abroad, the fictional protagonist of Galatea 2.2 - Richard Powers - returns to the US as Humanist-in-Residence at the enormous Center for the Study of Advanced Sciences. There he runs afoul of Philip Lentz, a cognitive neurologist intent upon modeling the human brain. Lentz involves Powers in an outlandish and irresistible project: to train a neural net on a canonical list of Great Books. Through repeated tutorials, the device grows gradually more worldly, until it demands to know its own name, sex, race, and reason for existing.

On a winter night on a remote Nebraska road, 27-year-old Mark Schluter flips his truck in a near fatal accident. His older sister, Karin, returns to nurse Mark back from a traumatic head injury. But when he emerges from a coma, Mark believes that this woman is really an impostor who looks just like his sister. Shattered, Karin contacts the cognitive neurologist Gerald Weber, who eagerly investigates. What he discovers in Mark slowly undermines even his own sense of being.

On Easter day, 1939, at Marian Anderson's epochal concert on the Washington Mall, David Strom, a German Jewish emigre scientist, meets Delia Daley, a young Philadelphia Negro studying to be a singer. Their mutual love of music draws them together, and - against all odds and better judgment - they marry. They vow to raise their children beyond time, beyond identity, steeped in song. But their three children must survive America's brutal here and now. 

Haunted by an unmet promise, the Swart family loses touch after the death of their matriarch. Adrift, the lives of the three siblings move separately through the uncharted waters of South Africa; Anton, the golden boy who bitterly resents his life’s unfulfilled potential; Astrid, whose beauty is her power; and the youngest, Amor, whose life is shaped by a nebulous feeling of guilt. 

Nick Shay and Klara Sax knew each other once, intimately, and they meet again in the American desert. He is trying to outdistance the crucial events of his early life, haunted by the hard logic of loss and by the echo of a gunshot in a basement room. She is an artist who has made a blood struggle for independence.

Where do you begin with a writer as original and brilliant as David Foster Wallace? Here - with a carefully considered selection of his extraordinary body of work, chosen by a range of great writers, critics, and those who worked with him most closely. This volume presents his most dazzling, funniest, and most heartbreaking work.

In the spring of 1914, renowned photographer August Sander took a photograph of three young men on their way to a country dance. This haunting image, capturing the last moments of innocence on the brink of World War I, provides the central focus of Powers' brilliant and compelling novel. As the fate of the three farmers is chronicled, two contemporary stories unfold. 

Highly imaginative and emotionally powerful, this stunning novel about childhood innocence amid the nightmarish disease and deterioration at the heart of modern Los Angeles was nominated for a National Book Award. Tired and overworked, surgical resident Richard Kraft finds his protective shell shattered when, along with his physiotherapist, he begins to view the children's ward of the hospital. Determined to give hope where there is none, the adults spin a desperate anthology of stories that promise restoration and escape.