Christmas is one of the most harrowing times of year for the nurses of St Angelus Hospital.  The Matron takes on Tilly, a new clerk, to ease the load in the busy festive period. Tilly is bright and hardworking, but she is keeping a secret from her colleagues. Everyday Tilly makes a heartbreaking decision - but she has no other choice. If Matron - with her traditional values and strict discipline -learnt the truth about her new clerk, Tilly's career would be ruined. Could Matron ever forgive the deceit?

Cambridgeshire - March 1939. As the clouds of war begin to gather in Europe, the Talbot family of rural Blackberry Farm will be torn apart, just as so many families all over the world will be. Life will never be the same again. Whilst in London, the Salmons family will feel the pain of parting and loss. Brought together by war, the two families become intertwined and, as the outlook looks bleak, they must draw on each other’s strength to fight through the hard times.

It is 1953, and five girls are arriving to start their training at St Angelus Hospital. Dana has escaped from her family farm in Ireland. Victoria is running away from an aristocratic background. Beth is an army brat and throws her lot in with bitchy Celia Forsyth, and Pammy has come from the wrong side of the tracks. When an unknown girl is admitted after a botched backstreet abortion, a tragedy begins to unfold which will rock the world of St Angelus to its foundations.

As a small child, Nellie Peace was always dreaming but sensed her mother’s rejection. Abandoned and sent into service at Beaumont House at an early age, Nellie is lost and alone until she meets the unpredictable and reclusive artist Lucas Harrington and falls in love with him. This unlikely association between master and servant is encouraged by Lucas’ gentle-natured Aunt Alice, as Lucas sees something unusual in Nellie and is compelled to paint her. Broken promises lead to inevitable heartbreak, and Nellie flees Beaumont House in disgrace for London.

Maureen Jackson is a prisoner of her father's blackmail. Three years ago, she'd been hoping to marry Rory, the man of her dreams. However, after her mother's death, Maureen was left to care for her overbearing father. Now Rory is back in London with his pregnant wife and reminds Maureen of the life that should have been hers. With the war looming, Janet Ashley hopes to marry her sweetheart Mike, but her father refuses to grant them his blessing. Janet finds herself pregnant and her mother Peggy is determined to hold her family together.

Lady Joanna Harcourt and her daughter, Sarah, discover their life of luxury at Goodwill House is over. Because with Lord Harcourt away fighting, the Harcourt girls are facing financial ruin. Lady Joanna is terrified of losing their home, but for Sarah, this means her dreams of becoming a doctor are over. Headstrong Sarah isn’t one to quit! War or not, she’s determined to find a way to save her home and follow her dreams - whatever it takes.

Jane Hadley has nothing to lose when she runs away to join the Women's Auxiliary Air Force. Whatever faces her in war-torn London can't be any worse than staying at home with her abusive father. The city is nothing like she could have imagined, but she's soon on the move, travelling from base to base for her top-secret training. Making plenty of friends along the way, it doesn't take long for Jane to embrace her growing confidence - especially under the attentive eye of dashing Officer Oscar Stanton.

Liverpool, 1939. Bella Rogers thought her life was just starting; she can’t wait to get married to her childhood sweetheart, Bobby. But when war is declared and Bobby is called up, his letters stop, leaving Bella heartbroken and alone. Then her family is torn apart by tragedy when her angelic 5-year-old sister dies from a terrible illness. They can barely afford a funeral, but the church is packed with the entire community, devastated for their loss. Grieving for her sister and lost love, Bella finds a job at the Bryant and May factory, making matches.

When Sally, Beth, Margaret and Rachel meet at a job interview for the wonderful new store in Oxford Street, they have no idea they will become lifelong friends. When all four girls are lucky enough to be selected as sales staff their exciting new adventure begins. Join them as they overcome heartbreak and grief, find love and happiness and remain united in their friendship, whatever life throws at them.

After failing to help evacuee siblings whom she witnesses being separated, May wishes she’d had the confidence to speak up. When Jess suggests a pantomime to boost morale on the station, May is desperate to help - but is held back by her own insecurities. With her low self-esteem also affecting her relationship with Squadron Leader Peter Travis, May is fed up with being her own worst enemy and decides to take charge of her destiny. But the past she ran from, plus a crisis with one of the evacuees, throw May into the midst of a drama that will test all of her newfound confidence. 

London, 1935. Ruby is always hungry, but she will go without if it means her young brothers can eat. 1930s Bermondsey might be called the larder of London, with its pie, pickle and jam factories, but for the poor working classes, starvation is often only a heartbeat away. When Ruby's neighbour suggests she ought to go to the Methodist Mission for free food, Ruby knows her father will be furious, but she has no other option.

London, 1910. Lily is 10 years old when she realises her grandmother, a washerwoman, is seriously ill. She's determined to do what she can to help and keep her grandmother's illness a secret - even from her beloved twin, Artie. When tragedy strikes and the twins are faced with the prospect of a workhouse or an orphanage, a benefactor offers to take Artie in and educate him. All Artie's needs will be taken care of - but the gentleman has no use for a girl. As the orphan twins grow up and take different paths, their new lives are beyond anything they could have imagined. 

London, 1940. After her fiancé breaks off their engagement, Evelyn decides to do her part for the war effort by signing up for construction work on Waterloo Bridge. Grieving after her little boy dies in an air raid, Gwen is completely lost when her husband sends their younger children to the countryside for safety. Enlisting as a construction worker, she is partnered with cheerful Evelyn. The two women strike up a heartwarming friendship. 

London, 1938: Lizzie Larch is a 20-year-old hat maker in London's east end. She is happy and popular, but she carries a secret. Seven years ago she was viciously attacked and recovered in a private sanatorium where she miscarried a child. Lizzie has no memory of the night of the attack, but secrets cannot stay secret for too long. When she starts courting her boss' nephew, a shocking revelation surfaces; threatening to destroy their new-found happiness.

After the heartbreak of World War Two, newlywed midwife Cathy hoped Liverpool life would offer some joy. But a terrible miscarriage and the escape of her abusive stepfather Jack from prison make happiness hard to find. Meanwhile, Cathy’s beloved granny is ailing. Whilst at the hospital, Cathy sees her midwifery friends, who are planning to open a home for unmarried mothers. After losing a baby of her own, Cathy would love to help, but for now, she must take care of her grandmother.