Edinburgh, 1849. Hordes of patients are dying all across the city, with doctors finding their remedies powerless. And a whispering campaign seeks to paint Dr. James Simpson, pioneer of medical chloroform, as a murderer. Determined to clear Simpson’s name, his protégé Will Raven and former housemaid Sarah Fisher must plunge into Edinburgh’s deadliest streets and find out who or what is behind the deaths. Soon they discover that the cause of the deaths has evaded detection purely because it is so unthinkable.

Dr Will Raven is a man seldom shocked by human remains, but even he is disturbed by the contents of a package washed up at the Port of Leith. Stranger still, a man Raven has long detested is pleading for his help to escape the hangman. Back in the townhouse of Dr James Simpson, Sarah Fisher has set her sights on learning to practise medicine. Almost everyone seems intent on dissuading her from this ambition, but when word reaches her that a woman has recently obtained a medical degree despite her gender, Sarah decides to seek her out.

Dr. Will Raven is a man seldom shocked by human remains, but even he is disturbed by the contents of a package washed up at the Port of Leith. Stranger still, a man Raven has long detested is pleading for his help to escape the hangman. Back in the townhouse of Dr. James Simpson, Sarah Fisher has set her sights on learning to practice medicine. Almost everyone seems intent on dissuading her from this ambition, but when word reaches her that a woman has recently obtained a medical degree despite her gender, Sarah decides to seek her out.

When a guest at a séance dies under suspicious circumstances, Inspector Haze and Lord Redmond quickly realize his death was a cleverly plotted execution. The main suspects are the other guests - including Daniel’s wife Sarah. Delving into the life of the deceased reveals a growing list of possible suspects, while the motive remains elusive.

One advantage of being caught up in a whirl of dress fittings and decisions about flower arrangements is that Charlotte Sloane has little time for any pre-wedding qualms. Her love for Wrexford isn't in question. But will being a wife - and a countess - make it difficult for her to maintain her independence - not to mention, her secret identity as famed satirical artist A. J. Quill? Despite those concerns, there are soon even more urgent matters to attend to during Charlotte and Wrexford's first public outing as an engaged couple.

London, September 1666. The Great Fire rages through the city, consuming everything in its path. Even the impregnable cathedral of St. Paul's is engulfed in flames and reduced to ruins. Among the crowds watching its destruction is James Marwood, son of a disgraced printer and reluctant government informer. In the aftermath of the fire, a semi-mummified body is discovered in the ashes of St. Paul's, in a tomb that should have been empty. The man's body has been mutilated, and his thumbs have been tied behind his back.

Before Jack the Ripper terrorised London, Police Inspector Samuel Ravenscroft patrolled the streets of Whitechapel. Clever and hard-working, Ravenscroft nonetheless has the worst record in the force. He lets a murderer escape during a chase and is banished to the spa town of Malvern for a water treatment to cure his asthma. Ravenscroft accepts a dinner invitation from a new acquaintance, Jabez Pitzer. Before dinner, the maid finds Pitzer slumped over his desk - dead. Ravenscroft immediately recognises the signs - Pitzer has been poisoned.

The Earl of Wrexford possesses a brilliant scientific mind, but boredom and pride lead him to reckless behavior. He does not suffer fools gladly. So when pompous, pious Reverend Josiah Holworthy publicly condemns him for debauchery, Wrexford unsheathes his rapier-sharp wit and strikes back. As their war of words escalates, London's most popular satirical cartoonist, A. J. Quill, skewers them both.

Singapore, 1910 - Desperate for a fresh start, Harriet Gordon finds herself living with her brother, a reverend and headmaster of a school for boys, in Singapore at the height of colonial rule. Hoping to gain some financial independence, she advertises her services as a personal secretary. It is unfortunate that she should discover her first client, Sir Oswald Newbold - explorer, mine magnate, and president of the exclusive Explorers and Geographers Club - dead with a knife in his throat.

When a man’s naked corpse is found strapped to a waterwheel, newly appointed Inspector Haze is called upon to investigate the crime. With the help of American surgeon Captain Redmond, he delves into the life of Frank Darrow, a man who inspired such hatred, his mere death wasn’t enough to satisfy his killer. Finding few clues and no obvious motive for the murder, Redmond and Haze must peel away the layers of Frank Darrow’s relationships to get to the shocking truth, while also coming to terms with unexpected developments in their own lives.