Reduced life expectancy, worsening health outcomes, health inequity, and declining health-care options - these are now realities for most Americans. However, in a country of more than 325 million people, addressing everyone's issues is challenging. How can we effect beneficial change for everyone so we all can thrive? What is the great equalizer?

In this brilliant book, Isabel Wilkerson gives us a masterful portrait of an unseen phenomenon in America as she explores, through an immersive, deeply researched narrative and stories about real people, how America today and throughout its history has been shaped by a hidden caste system, a rigid hierarchy of human rankings. Beautifully written, original, and revealing, Caste: The Origins of Our Discontents is an eye-opening story of people and history, and a reexamination of what lies under the surface of ordinary lives and of American life today. 

Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells - taken without her knowledge - became one of the most important tools in medicine: The first “immortal” human cells grown in culture, which are still alive today, though she has been dead for more than 60 years. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects.

Most Americans believe that slavery was a creature of the South, and that Northern states and territories provided stops on the Underground Railroad for fugitive slaves on their way to Canada. In this paradigm-shifting book, celebrated historian Tiya Miles reveals that slavery was at the heart of the Midwest's iconic city: Detroit. In this richly researched and eye-opening book, Miles has pieced together the experience of the unfree - both native and African American - in the frontier outpost of Detroit.

The grandson of a slave, Dr. Ossian Sweet moved his family to an all-white Detroit neighborhood in 1925. When his neighbors attempted to drive him out, Sweet defended himself, resulting in the death of a white man and a murder trial for Sweet. There followed one of the most important (and shockingly unknown) cases in Civil Rights history. Also caught up in the intense courtroom drama were legal giant Clarence Darrow and the newly formed National Association for the Advancement of Colored People (NAACP).

In the tradition of the best writing on medicine, physician and reporter Sheri Fink reconstructs five days at Memorial Medical Center and draws the listener into the lives of those who struggled mightily to survive and to maintain life amidst chaos. After Katrina struck and the floodwaters rose, the power failed, and the heat climbed, exhausted caregivers chose to designate certain patients last for rescue. Months later, several health professionals faced criminal allegations that they deliberately injected numerous patients with drugs to hasten their deaths.

Discover Malcolm Gladwell's breakthrough debut and explore the science behind viral trends in business, marketing, and human behavior. The tipping point is that magic moment when an idea, trend, or social behavior crosses a threshold, tips, and spreads like wildfire. Just as a single sick person can start an epidemic of the flu, so too can a small but precisely targeted push cause a fashion trend, the popularity of a new product, or a drop in the crime rate.

1915. In German-occupied Belgium, a tragic loss forces Josephine Descharmes to navigate dangerous new territory. By day it’s compliance, serving German officers at the Hotel Métropole. By night it’s resistance, working with her brothers underground to help Allied soldiers and civilians cross the border into Holland. Both paths put her and her family at great risk. As Josephine struggles to keep her family safe, Arthur, a grief-stricken English soldier trapped behind enemy lines, finds purpose and hope with Josephine and her work. 

When three-month-old Lia Lee arrived at the county hospital emergency room in Merced, California, a chain of events was set in motion from which neither she nor her parents nor her doctors would ever recover. Lia's parents, Foua and Nao Kao, were part of a large Hmong community in Merced, refugees from the CIA-run "Quiet War" in Laos.

In Shock is a riveting first-hand account from a young critical care physician, who in the passage of a moment is transfigured into a dying patient. This transposition, coincidentally timed at the end of her medical training, instantly lays bare the vast chasm between the conventional practice of medicine and the stark reality of the prostrate patient.

Pulitzer Prize-winner Tracy Kidder tells the true story of a socially conscious genius who uses his intellectual and personal gifts to solve global health problems.

In 1965, a new immigration law lifted a century of restrictions against Asian immigrants to the United States. Nobody, including the lawmakers who passed the bill, expected it to transform the country’s demographics. But over the next four decades, millions arrived, including Jay Caspian Kang’s parents, grandparents, aunts, and uncles. They came with almost no understanding of their new home, much less the history of “Asian America” that was supposed to define them.

In his audiobook, A Higher Loyalty, former FBI director James Comey shares his never-before-told experiences from some of the highest stakes situations of his career in the past two decades of American government, exploring what good, ethical leadership looks like and how it drives sound decisions. His journey provides an unprecedented entry into the corridors of powe, and a remarkable lesson in what makes an effective leader.

How can we summon a moment of lift for human beings - and especially for women? Because, when you lift up women, you lift up humanity. For the last 20 years, Melinda Gates has been on a mission to find solutions for people with the most urgent needs, wherever they live. Throughout this journey, one thing has become increasingly clear to her: If you want to lift society up, you need to stop keeping women down.

In Anna Clark's full account of this American tragedy, The Poisoned City recounts the gripping story of Flint’s poisoned water through the people who caused it, suffered from it, and exposed it. It is a chronicle of one town, but could also be about any American city, all made precarious by the neglect of infrastructure and the erosion of democratic decision making. Places like Flint are set up to fail - and for the people who live and work in them, the consequences can be fatal. 

By reckoning with the big challenges we face together, drawing on the hard-won wisdom and insight from her own career and the work of those who have most inspired her, Kamala Harris offers in The Truths We Hold a master class in problem solving, in crisis management, and leadership in challenging times. Through the arc of her own life, on into the great work of our day, she communicates a vision of shared struggle, shared purpose, and shared values.

One day in 2002 the 50-year old body of former Pittsburgh Steeler and hall of famer Mike Webster was laid on a cold table in front of pathologist Dr. Bennet Omalu. Webster's body looked to Omalu like the body of a much older man, and the circumstances of his behavior prior to his death were clouded in mystery. But when Omalu cut into Webster's brain, it appeared to be normal. Something didn't add up.

Nearly 75 years ago, Donald Triplett of Forest, Mississippi, became the first child diagnosed with autism. Beginning with his family's odyssey, In a Different Key tells the extraordinary story of this often misunderstood condition and of the civil rights battles waged by the families of those who have it. Unfolding over decades, it is a beautifully rendered history of ordinary people determined to secure a place in the world for those with autism.

A riveting, powerful telling of the story of the grassroots movement of activists, many of them in a life-or-death struggle, who seized upon scientific research to help develop the drugs that turned HIV from a mostly fatal infection to a manageable disease. Ignored by public officials, religious leaders, and the nation at large, and confronted with shame and hatred, this small group of men and women chose to fight for their right to live by educating themselves and demanding to become full partners in the race for effective treatments.

Who are the children of foster care? What, as a country, do we owe them? Cris Beam, a foster mother herself, spent five years immersed in the world of foster care looking into these questions and tracing firsthand stories. The result is To the End of June, an unforgettable portrait that takes us deep inside the lives of foster children in their search for a stable, loving family. Beam shows us the intricacies of growing up in the system - the back-and-forth with agencies, the rootless shuffling between homes, the emotionally charged tug between foster and birth parents.

"The ultimate Obama insider" (The New York Times) and longest-serving senior advisor in the Obama White House shares her journey as a daughter, mother, lawyer, business leader, public servant, and leader in government at a historic moment in American history. 

In just over a decade, John Hickenlooper has gone from a craft-brew entrepreneur to mayor of Denver to governor of Colorado, hailed by many political analysts, The New York Times, and Fox News alike as a solid contender to be the next vice president. It is an unlikely tale of success, quintessentially American yet utterly exceptional. In The Opposite of Woe, Hickenlooper tells his own story of determination and daring, from business to politics, in his singularly sharp and often hilarious voice.

Salk became a cultural hero and icon for a whole generation. Now, at the fiftieth anniversary of the first national vaccination program, and as humanity is tantalizingly close to eradicating polio worldwide, comes this unforgettable chronicle. Salk's work was an unparalleled achievement, and it makes for a magnificent listen.

In November 2014, 13 members of the Biden family gathered on Nantucket for Thanksgiving, a tradition they had been celebrating for the past 40 years; it was the one constant in what had become a hectic, scrutinized, and overscheduled life. The Thanksgiving holiday was a much-needed respite, a time to connect, a time to reflect on what the year had brought, and what the future might hold. But this year felt different from all those that had come before.