For years, many have believed that the rise of superpowered mutants represents a threat to the survival of ordinary humans. The uncanny X-Men have dedicated their lives to proving that peaceful coexistence is possible. When a refugee spacecraft crashes on Earth, hounded by a warship bent on its destruction, the X-Men race to the rescue - only to learn that it carries beings of an entirely different order whose very existence may jeopardize life as we know it.

The Avengers journey into deep space, where they unite the intergalactic races against the Builders - deadly aliens who seek to destroy the known galaxy. While the heroes are gone, Thanos sets his sights on Earth, sending the Black Order to launch the assault. It falls to the other heroes of Earth - the Inhumans, the Black Panther, Namor the Sub-Mariner, Doctor Strange, the X-Men, and more - to defend Attilan, Wakanda, Atlantis, and the rest of the planet. To defeat Thanos, the defending forces will need to deploy a new weapon - one that may be as deadly as the invading force. 

The fate of the entire Marvel Universe hangs in the balance as Earth's mightiest heroes face their greatest challenge! Summoned across the stars by the mysterious and unbelievably powerful Beyonder, the Avengers, Spider-Man, the Fantastic Four, and the X-Men are set against their deadliest foes on the mysterious planet known as Battleworld - with the winner promised the ultimate prize. But as battle lines are drawn, new alliances are forged, and old enemies clash, one among them is not willing to settle for anything less than godhood.

Iron Man and Captain America are two core members of the Avengers, the world's greatest superhero team. But when a tragic battle blows a hole in the city of Stamford, killing hundreds of people, the US government demands that all superheroes unmask and register their powers. To Tony Stark - Iron Man - it's a regrettable but necessary step. To Captain America, it's an unbearable assault on civil liberties. 

Magneto, the X-Men's oldest, deadliest foe, has taken over a top-secret government installation that houses the Sentinels, powerful mutant-hunting robots. The X-Men must fight to keep this deadly technology out of Magneto's hands. But the Acolytes, Magneto's fanatical mutant followers, stand between the X-Men and victory - a victory that’s quickly slipping away - for a more ruthless enemy, the US government, holds the X-Men responsible for the installation's takeover!  

This gripping new anthology has over a dozen original tales starring the top-selling mutant heroes, the uncanny X-Men, dealing with their greatest foes, as well as the day-to-day trials of being mutants - trying to protect the world they've sworn to protect, a world that hates them for what they are! 

Professor X, the X-Men's founder and mentor, and Shi'ar Empress Lilandra have been forced to love each other from afar - he has to remain on Earth to lead the X-Men, and she must stay with the Shi'ar to run the empire. Now, Lilandra must turn to the X-Men for help against a threat to her domain - and possibly the Earth as well. Shi'ar scientists have learned of a creature that devours galaxies and is heading toward Shi'ar space.

In a dark and dangerous future, the mutant-hunting machines known as the Sentinels rule America with an iron fist. Almost all mutants and superhumans have been exterminated. Only a handful of imprisoned mutants remain to fight against their oppressive robotic overseers! Now Kate Pryde, former X-Man, must travel back in time and warn her present-day teammates of the coming danger - and hopefully prevent this horrible future from ever taking place!

This exciting new anthology has over a dozen original tales starring the vicious foes of Marvel's superheroes: Greg Cox's chronicle of the Super-Skrull's conflict with the Avengers, Michael Jan Friendman's story of evil Loki's latest attempt to snare his stepbrother Thor, Adam-Troy Castro's tale of a mutant who brings Magneto and X-Men's Professor X together in a unique manner, Glenn Greenberg's pairing of Venom and the Absorbing Man in an unlikely jailbreak. 

Piloting a shuttle through a deadly solar flare, Jean Grey saves the X-Men, but is possessed by one of the universe's most powerful forces - the Phoenix. As she adapts to her new powers, the mutant team launches an assault against the clandestine organization known as the Hellfire Club. Once inside, however, Jean is tricked by the villain Mastermind into betraying her teammates. She becomes first the Hellfire Club's Black Queen and then Dark Phoenix, as the power to destroy worlds bursts forth uncontrolled.

An arsonist's twisted handiwork claims hundreds of lives in the roughest neighborhood in New York - Daredevil's turf. Daredevil digs up the root of the problem and comes up with a ruthless crime boss bent on brutally wrestling control of New York's underworld from the corrupt clutches of the Kingpin of Crime. The new crime boss' enforcer? The bloodthirsty Bullseye, master assassin with a pathological enmity for Daredevil. Bullseye takes to his work with deadly efficiency, killing his way toward the Man Without Fear.

Betrayed by Earth's heroes and exiled into outer space, the man-monster known as the Incredible Hulk has landed on the distant planet Sakaar, ruled by the tyrannical Red King. Sold into slavery, the Hulk becomes the Green Scar, the planet's mightiest gladiator! But his new masters get more than they bargained for when he forges a bond of brotherhood with his fellow fighters: crafty insectoid Miek, the horrific Brood, wise rock-man Korg, Shadow Warrior Hiroim, noble-born rebel Elloe, and her loyal guardsman Skee. Together, these gladiators start a revolution.

Jean Grey awakens in an unfamiliar room. She is weak, disoriented, stripped of her telepathic and telekinetic powers - and trapped in someone else's body. Also prisoner are her teammates Cyclops, Wolverine, Rogue, and Nightcrawler - their minds held hostage within the bodies of strangers. Who has brought them here, and for what purpose? The answers lead to a terrifying plan that threatens not only the X-Men, but all of mutantkind.

Hydra has a synthetic pathogen that will make the entire human race dependent on them for the cure. A.I.M.'s newly developed nanotech compound to enslave humanity is dangerously close to contaminating the world's water supplies. Ultron is poised on the edge of Singularity, Earth's technology at his metallic fingertips. Dormammu has a plan to save the world - by claiming it as his own. The High Evolutionary is rewriting the human genome in a bid to turn humankind into a eugenic slave-race. Everybody wants to rule the world - and only the isolated Avengers can stop them.

On several occasions, a half-dozen of Spider-Man's greatest enemies have banded together as the Sinister Six. Now, at the behest of a deadly benefactor known only as the Gentleman, the Chameleon has been tasked with assembling a new Sinister Six with the most ambitious scheme yet! Soon, he has recruited the Vulture, freed Electro and Dr. Octopus from prison, and been joined by the Gentleman's mysterious ward, Pity. That only leaves Mysterio, but the master of illusion has a plan of his own.