When the Scarlet Witch of the Avengers and Rogue of the X-Men all disappear under mysterious circumstances, each team's search leads them to more questions than answers. When the X-Men appear to attack a high-security government installation, the Avengers must track down the mutants and learn the truth behind the abductions before it's too late. 

Iron Man, Thor, Vision, The Beast, Quicksilver, and The Scarlet Witch band together to save the life of Captain America, the living legend of World War II! Travel with these six sensational heroes 2,000 years into the future as they come face-to-face with the unimaginable villainy of Kang the Conqueror, a descendant of Dr. Doom who is determined to be rid of Captain America—for good. 

Brian Timilty is running for mayor on an anti-superhero ticket, and the amazing Spider-Man is his biggest target. But Timilty is secretly the pawn of Tyler Stewart, a wealthy businessman seeking to take over New York's mobs. To ensure his success, Stewart hires two of Spider-Man's deadliest foes, Electro and the Rhino, and executes a plan guaranteed to keep the wall-crawler from interfering with his grand designs: He frames Spider-Man for a grisly murder! Forced into hiding, Spider-Man must find a way to clear his name without being shot on sight, for he is wanted dead or alive.

Centuries ago, a never-before-seen group of heroes gathered as the Avengers of their ancient era to fight the Zodiac, foes who wielded unimaginable arcane energies channeled through a mysterious Key. The resulting battle devastated vast swaths of the planet. The Key was lost, and the Zodiac went into hiding, influencing world events from the shadows, waiting for the stars to align to usher in their return. When strange beings exhibiting the traits of the 12 astrological signs appear in the 21st century, the Avengers again answer the call to assemble. 

An alien race calling themselves the Kh'thon descend upon the planet, announcing that they are the former occupants and rightful owners of Earth. The evidence they present is startling: Their ships are manned by Homo sapiens, supposedly descendants of human beings who served the Kh'thon on Earth countless millennia ago, and their will is enforced by the Exemplar, humans augmented with a dizzying array of powers, each the match of any one of the X-Men.  

Under the direction of the brilliant, unscrupulous, and enigmatic Professor, Logan begins an agonizing transformation process to harness his mutant powers and forge him into “Weapon X” - an unstoppable, indestructible killing machine, a bringer of mayhem with retractable harder-than-diamond steel claws and the ability to recover from any wound. 

Dr. Bruce Banner. Emil Blonsky. One a brilliant scientist, the other an agent for the KBG. Both men whose lives were irrevocably altered by gamma radiation - transforming Banner into the incredible Hulk and Blonsky into the deadly Abomination. For years, the two super-strong creatures have clashed. Now they are brought together for their most deadly confrontation yet. The Abomination has allied himself with the URSA, an organization dedicated to restoring the Soviet Union - but he is using the URSA to further his own mad quest for vengeance on all those who wronged him in life.

The fate of the entire Marvel Universe hangs in the balance as Earth's mightiest heroes face their greatest challenge! Summoned across the stars by the mysterious and unbelievably powerful Beyonder, the Avengers, Spider-Man, the Fantastic Four, and the X-Men are set against their deadliest foes on the mysterious planet known as Battleworld - with the winner promised the ultimate prize. But as battle lines are drawn, new alliances are forged, and old enemies clash, one among them is not willing to settle for anything less than godhood.

Magneto, the X-Men's oldest, deadliest foe, has taken over a top-secret government installation that houses the Sentinels, powerful mutant-hunting robots. The X-Men must fight to keep this deadly technology out of Magneto's hands. But the Acolytes, Magneto's fanatical mutant followers, stand between the X-Men and victory - a victory that’s quickly slipping away - for a more ruthless enemy, the US government, holds the X-Men responsible for the installation's takeover!  

In a Manhattan warehouse, an innocent man has been murdered during a mysterious crime. Evidence points to the involvement of Venom - the alien symbiote obsessed with Spider-Man's destruction. Yet Venom has always safeguarded innocent lives. Has Venom gone completely around the bend, or is there another suspect? Spider-Man thinks there is more to the crime than meets the eye. The specter of the Hobgoblin, one of Spider-Man's nastiest foes, falls on a series of thefts and leads the web-slinger to a deadly secret that may cause New York's destruction. 

Piloting a shuttle through a deadly solar flare, Jean Grey saves the X-Men, but is possessed by one of the universe's most powerful forces - the Phoenix. As she adapts to her new powers, the mutant team launches an assault against the clandestine organization known as the Hellfire Club. Once inside, however, Jean is tricked by the villain Mastermind into betraying her teammates. She becomes first the Hellfire Club's Black Queen and then Dark Phoenix, as the power to destroy worlds bursts forth uncontrolled.

The Avengers journey into deep space, where they unite the intergalactic races against the Builders - deadly aliens who seek to destroy the known galaxy. While the heroes are gone, Thanos sets his sights on Earth, sending the Black Order to launch the assault. It falls to the other heroes of Earth - the Inhumans, the Black Panther, Namor the Sub-Mariner, Doctor Strange, the X-Men, and more - to defend Attilan, Wakanda, Atlantis, and the rest of the planet. To defeat Thanos, the defending forces will need to deploy a new weapon - one that may be as deadly as the invading force. 

On several occasions, a half-dozen of Spider-Man's greatest enemies have banded together as the Sinister Six. Now, at the behest of a deadly benefactor known only as the Gentleman, the Chameleon has been tasked with assembling a new Sinister Six with the most ambitious scheme yet! Soon, he has recruited the Vulture, freed Electro and Dr. Octopus from prison, and been joined by the Gentleman's mysterious ward, Pity. That only leaves Mysterio, but the master of illusion has a plan of his own. 

Hydra has a synthetic pathogen that will make the entire human race dependent on them for the cure. A.I.M.'s newly developed nanotech compound to enslave humanity is dangerously close to contaminating the world's water supplies. Ultron is poised on the edge of Singularity, Earth's technology at his metallic fingertips. Dormammu has a plan to save the world - by claiming it as his own. The High Evolutionary is rewriting the human genome in a bid to turn humankind into a eugenic slave-race. Everybody wants to rule the world - and only the isolated Avengers can stop them.

Under secret orders to assassinate the Widow, Hawkeye, the rough-edged marksman, finds himself caught up in a violent prison break that releases some of the world's most vicious and powerful criminals. Defying his superiors, Hawkeye joins forces with the sultry Russian spy and a mismatched group of personalities that include Spider-Man, Spider-Woman, Luke Cage, Captain America, and Iron Man.